GTF3C3 antibody

Principal name

GTF3C3 antibody

Alternative names for GTF3C3 antibody

Transcription factor IIIC subunit gamma, TFIIIC 102 kDa subunit, TFIIIC102, TFIIIC gamma, General transcription factor 3C polypeptide 3

SwissProt ID

Q9Y5Q9 (Human)

Gene ID

9330 (GTF3C3)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Bov (Bovine), Eq (Equine), Por (Porcine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), Paraffin Sections (P)

Background of GTF3C3 antibody

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

General readings

Zhan,Y., et al., (2002) Cell Death Differ. 9 (4), 439-447

13 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GTF3C3 antibody

  Rabbit polyclonal anti-TF3C3 antibody  
Western blot analysis of extracts from 293 cells, using TF3C3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GTF3C3 antibody

  Rabbit Polyclonal Anti-GTF3C3 Antibody  
WB Suggested Anti-GTF3C3 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysateGTF3C3 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GTF3C3 antibody

  Rabbit Polyclonal Anti-GTF3C3 Antibody  
WB Suggested Anti-GTF3C3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: 721_B cell lysate. GTF3C3 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GTF3C3 antibody

Immunohistochemistry  (IHC) analyzes of TFIIIC102 antibody (Cat.-No.: AP20464PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GTF3C3 antibody

Western blot analysis of extracts from 293 cells, using TF3C3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

GTF3C3 antibody

Western blot analysis of extracts from 293 cells, using TF3C3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

GTF3C3 - human gene knockout kit via CRISPR

GTF3C3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GTF3C3 - human gene knockout kit via CRISPR

GTF3C3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GTF3C3 - human gene knockout kit via CRISPR

GTF3C3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GTF3C3 - human gene knockout kit via CRISPR

GTF3C3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GTF3C3 overexpression lysate

GTF3C3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GTF3C3 (mGFP-tagged) - Human general transcription factor IIIC, polypeptide 3, 102kDa (GTF3C3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GTF3C3 (mGFP-tagged) - Human general transcription factor IIIC, polypeptide 3, 102kDa (GTF3C3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GTF3C3 (Myc-DDK tagged) - Human general transcription factor IIIC, polypeptide 3, 102kDa (GTF3C3), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GTF3C3 (Myc-DDK tagged) - Human general transcription factor IIIC, polypeptide 3, 102kDa (GTF3C3), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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