GTP-binding protein 1 / GBP1 antibody

Principal name

GTP-binding protein 1 / GBP1 antibody

Alternative names for GTP-binding protein 1 / GBP1 antibody

Guanine nucleotide-binding protein 1, HuGBP-1, Interferon-induced guanylate-binding protein 1

SwissProt ID

P32455 (Human), Q01514 (Mouse)

Gene ID

2633 (GBP1)

Available reactivities

Hu (Human), Bov (Bovine), Rt (Rat), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of GTP-binding protein 1 / GBP1 antibody

GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage step, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-γ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi’s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

General readings

Vopel, T., et al. J. Mol. Biol. 400(1):63-70(2010)
Mirpuri, J., et al. J. Immunol. 184(12):7186-7195(2010)
Lipnik, K., et al. Mol. Med. 16 (5-6), 177-187 (2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
O'Doherty, C., et al. Pharmacogenomics 10(7):1177-1186(2009)

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  2. Highly Validated (2)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GTP-binding protein 1 / GBP1 antibody

  GBP1 mouse monoclonal antibody, clone OTI1B2 (formerly 1B2)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-GBP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503589) Mouse IgG1 OTI1B2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GTP-binding protein 1 / GBP1 antibody

Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4D10 Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

GTP-binding protein 1 / GBP1 antibody

  Rabbit polyclonal anti-GBP1 antibody  
Western blot analysis of extracts from HUVEC cells, using GBP1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GTP-binding protein 1 / GBP1 antibody

  Rabbit Polyclonal GBP1 Antibody  
Western Blot: GBP1 Antibody [TA336885] - Analysis of GBP1 using GBP1 polyclonal antibody. Human HCT-116 lysate in the absence (1) and presence (2) of immunizing peptide and mouse RAW cell lysate (3) probed with GBP1 antibody at 3 ug/ml. Goat anti-rabbit I Rabbit Purified Hu, Ms C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GTP-binding protein 1 / GBP1 antibody

Western blot (WB) analysis of GBP1 antibody (Cat.-No.: AP01376PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GTP-binding protein 1 / GBP1 (N-term) antibody

Western blot analysis of GBP1 Antibody (N-term) Cat.-No AP51791PU-N in MDA-MB231 cell line lysates (35ug/lane). This demonstrates the GBP1 antibody detected the GBP1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GTP-binding protein 1 / GBP1 antibody

Immunofluorescence analysis of MCF7 cells, using GBP1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

GTP-binding protein 1 / GBP1 antibody

Immunofluorescence analysis of MCF7 cells, using GBP1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

GBP1 - human gene knockout kit via CRISPR

GBP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GBP1 - human gene knockout kit via CRISPR

GBP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GBP1 - human gene knockout kit via CRISPR

GBP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GBP1 - human gene knockout kit via CRISPR

GBP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GTP-binding protein 1 / GBP1

  Recombinant protein of human guanylate binding protein 1, interferon-inducible, 67kDa (GBP1)  
GTP-binding protein 1 / GBP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

13 Item(s)

per page
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