Guanylate cyclase soluble GUCY1A3 antibody

Principal name

Guanylate cyclase soluble GUCY1A3 antibody

Alternative names for Guanylate cyclase soluble GUCY1A3 antibody

GCS-alpha-3, GCS-alpha-1, GUC1A3, GUCSA3, GUCY1A1, sGC alpha, Guanylate cyclase soluble subunit alpha-3, Soluble guanylate cyclase large subunit

SwissProt ID

P19686 (Rat), Q02108 (Human), Q4ZHS0 (Canfa), Q9ERL9 (Mouse)

Gene ID

2982 (GUCY1A3), 60596 (Gucy1a3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Guanylate cyclase soluble GUCY1A3 antibody

The cellular levels of Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, are maintained by the orchestrated activities of two opposing enzymes: synthesizing gualylyl cyclases (GC) and hydrolyzing phosphodiesterases (PDEs). The synthesizing enzymes (GCs) are found in two forms: cytosolic (soluble) and membrane-bound (particulate). In last several years new members of particulate guanylate cyclase family have been identified and significant progress is made in understanding the molecular mechanisms that underlie the regulation of these family of enzymes. In response to G-protein couples receptor stimulation, the cGMP can be produced from GTP by either cytoplasmic, soluble guanylate cyclase (sGC) are heterodimers (a and b polypeptide chains), that are stimulated by nitric oxide and carbon monoxide or by particulate membrane-bound guanylyl cyclases which are activated by a complex mechanism by natriuretic peptides. Particulate GC (PGCs) have 7 different isoforms, PGC-A through PGC-G and are expressed in most tissues in isoform specific manner (See Table 1). There is significant structural homology among various PGCs, there is a large N-terminal extracellular domain (ECD), a single TMD and a large intracellular domain with protein kinase activity (KLD), a C-terminal catalytic domain (CD) and in between is a dimmerization domain (DD). It has been shown that a significant number hippocampal astrocytes (67%) contained both soluble and particulate guanylate cyclases in the same cell (2).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Guanylate cyclase soluble GUCY1A3 (N-term) antibody

  Rabbit Polyclonal Antibody against GUCY1A3 (N-term)  
Western blot analysis of GUCY1A3 (arrow) using GUCY1A3 Antibody (N-term) (Cat.#TA302112). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GUCY1A3 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Guanylate cyclase soluble GUCY1A3 antibody

  Rabbit Polyclonal Anti-GUCY1A3 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (GUCY1A3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Guanylate cyclase soluble GUCY1A3 control peptide

Guanylate cyclase soluble GUCY1A3
0.25 mg / €250.00
  Acris Antibodies GmbH

Guanylate cyclase soluble GUCY1A3 (C-term) antibody

Guanylate cyclase soluble GUCY1A3 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Guanylate cyclase soluble GUCY1A3 antibody

Western blot analysis of GCS-alpha-1 antibody (Cat.-No. AP20764PU-N) in extracts from THP1 cells. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Guanylate cyclase soluble GUCY1A3 antibody

Western Blot analysis of GUCY1A3 expression in transfected 293T cell line (H00002982-T01) by GUCY1A3 MaxPab polyclonal antibody.

Lane 1: GUCY1A3 transfected lysate(75.9 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Guanylate cyclase soluble GUCY1A3 antibody

Western Blot analysis of GUCY1A3 expression in transfected 293T cell line (H00002982-T01) by GUCY1A3 MaxPab polyclonal antibody.

Lane 1: GUCY1A3 transfected lysate(75.9 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Guanylate cyclase soluble GUCY1A3 antibody

Guanylate cyclase soluble GUCY1A3 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Guanylate cyclase soluble GUCY1A3 antibody

Western Blot analysis of GUCY1A3 expression in transfected 293T cell line (H00002982-T01) by GUCY1A3 MaxPab polyclonal antibody.

Lane 1: GUCY1A3 transfected lysate(77.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Guanylate cyclase soluble GUCY1A3 antibody

Detection limit for recombinant GST tagged GUCY1A3 is approximately 1ng/ml as a capture antibody. Mouse IgG2b 2H1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Guanylate cyclase soluble GUCY1A3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with GUCY1A3 polyclonal antibody ( Cat # PAB2683 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Guanylate cyclase soluble GUCY1A3 antibody

Immunohistochemical analysis of GUCY1A3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Por P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Guanylate cyclase soluble GUCY1A3 antibody

Immunohistochemical analysis of GUCY1A3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Por P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Guanylate cyclase soluble GUCY1A3 antibody

Immunohistochemical analysis of GUCY1A3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Por P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CRISPR

Catalog No. Species Donor Vector  

Gucy1a3 - mouse gene knockout kit via CRISPR

Gucy1a3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gucy1a3 - mouse gene knockout kit via CRISPR

Gucy1a3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gucy1a3 - mouse gene knockout kit via CRISPR

Gucy1a3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gucy1a3 - mouse gene knockout kit via CRISPR

Gucy1a3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Guanylate cyclase soluble GUCY1A3 (transcript variant 1)

  Recombinant protein of human guanylate cyclase 1, soluble, alpha 3 (GUCY1A3), transcript variant 1  
Guanylate cyclase soluble GUCY1A3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Guanylate cyclase soluble GUCY1A3

Guanylate cyclase soluble GUCY1A3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

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