GUP1 / HHATL antibody

Principal name

GUP1 / HHATL antibody

Alternative names for GUP1 / HHATL antibody

C3orf3, KIAA1173, Protein-cysteine N-palmitoyltransferase HHAT-like protein, Hedgehog acyltransferase-like protein, Glycerol uptake/transporter homolog

SwissProt ID

Q9D1G3 (Mouse), Q9HCP6 (Human)

Gene ID

57467 (HHATL)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of GUP1 / HHATL antibody

GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.

General readings

Abe Y, Kita Y, and Niikura T. Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-palmitoylation of Sonic hedgehog. FEBS J. 2008; 275:318-31.

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GUP1 / HHATL (N-term) antibody

Western blot analysis of HHATL in 3T3 cell lysate with HHATL antibody at 1 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GUP1 / HHATL (N-term) Control Peptide

GUP1 / HHATL
50 µg / €160.00
  Acris Antibodies GmbH

GUP1 / HHATL antibody

GUP1 / HHATL Mouse IgG1 2B7 Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

GUP1 / HHATL antibody

Immunohistochemistry-Paraffin: HHATL Antibody [NBP1-86791] Immunohistochemical staining of human heart muscle shows moderate cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GUP1 / HHATL

GUP1 / HHATL Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GUP1 / HHATL

GUP1 / HHATL Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

GUP1 / HHATL

GUP1 / HHATL Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GUP1 / HHATL

GUP1 / HHATL Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

8 Item(s)

per page
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