HAAO antibody

Principal name

HAAO antibody

Alternative names for HAAO antibody

3-hydroxyanthranilate oxygenase, HAD, 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilic acid dioxygenase

SwissProt ID

P46952 (Human), P46953 (Rat), P47096 (Yeast), Q0VCA8 (Bovin), Q6P7I0 (Xenla), Q78JT3 (Mouse), Q7SDX3 (Neucr)

Gene ID

23498 (HAAO), 107766 (Haao), 56823

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of HAAO antibody

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

General readings

Malherbe P., et al. (1994) J Biol Chem. 13;269(19):13792-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HAAO antibody

  Rabbit Polyclonal HAAO Antibody  
Western blot analysis of HAAO in Mouse liver tissue lysate with HAAO antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAAO (N-term) antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

HAAO antibody

HAAO Mouse IgG2b 4D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HAAO antibody

Human 293T; WB Suggested Anti-HAAO Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: 293T cell lysate; HAAO antibody - N-terminal region (ARP42356_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

HAAO antibody

HAAO Rabbit Aff - Purified Ms P
25 µg / €630.00
  Funakoshi Co., Ltd.

CRISPR

Catalog No. Species Donor Vector  

HAAO - human gene knockout kit via CRISPR

HAAO - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HAAO - human gene knockout kit via CRISPR

HAAO - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HAAO - human gene knockout kit via CRISPR

HAAO - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HAAO - human gene knockout kit via CRISPR

HAAO - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Haao - mouse gene knockout kit via CRISPR

Haao - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Haao - mouse gene knockout kit via CRISPR

Haao - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Haao - mouse gene knockout kit via CRISPR

Haao - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Haao - mouse gene knockout kit via CRISPR

Haao - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HAAO

  Recombinant protein of human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)  
HAAO Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

HAAO (1-286, His-tag)

HAAO Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

HAAO (1-286, His-tag)

HAAO Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

HAAO

HAAO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
10 µg / €380.00
  Abnova Taiwan Corp.

HAAO

HAAO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
25 µg / €510.00
  Abnova Taiwan Corp.

HAAO

HAAO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

HAAO

HAAO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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