HAX1 antibody

Principal name

HAX1 antibody

Alternative names for HAX1 antibody

HAX-1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1

SwissProt ID

O00165 (Human), O35387 (Mouse), Q2KIE2 (Bovin), Q7TSE9 (Rat)

Gene ID

10456 (HAX1), 23897 (Hax1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of HAX1 antibody

HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

General readings

Johns, H.L., et al. J. Gen. Virol. 91 (PT 11), 2677-2686 (2010)
Mekkawy, A.H., et al. Biochem. Biophys. Res. Commun. 399(4):738-743(2010)
Han, J., et al. J. Biol. Chem. 285(29):22461-22472(2010)
Germeshausen, M., et al. Haematologica 95(7):1207-1210(2010)
Burnicka-Turek, O., et al. BMC Cell Biol. 11, 28 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HAX1 (both Isoforms) antibody

  Goat Anti-HAX1 Antibody  
TA305662 (1ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Rabbit Polyclonal Hax1a Antibody  
Western blot analysis of Hax1a in human brain tissue lysate with Hax1a antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Rabbit Polyclonal Hax1b Antibody  
Western blot analysis of Hax1b in mouse brain tissue lysate with Hax1b antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Mouse Hax1a Monoclonal Antibody  
Western blot analysis of Hax1a in human brain tissue lysate with Hax1a antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 8F9G7 Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Mouse Hax1a Monoclonal Antibody  
Western blot analysis of Hax1a in human brain tissue lysate with Hax1a antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 9G3D11 Aff - Purified Hu, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Mouse Hax1a Monoclonal Antibody  
Western blot analysis of Hax1a in human heart tissue lysate with Hax1a antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 9G6C6 Aff - Purified Hu, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Rabbit anti-HAX1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using HAX1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Rabbit Polyclonal Anti-HAX1 Antibody  
WB Suggested Anti-HAX1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: COLO205 cell lysateHAX1 is supported by BioGPS gene expression data to be expressed in COLO205 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

  Rabbit Polyclonal Anti-HAX1 Antibody  
WB Suggested Anti-HAX1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

HAX1 antibody

Cell lysates of MCF7 (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human HAX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT3C5 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

HAX1 antibody

Cell lysates of MCF7 (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human HAX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT3C5 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

HAX1 (C-term) antibody

Imunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma reacted with HAX1 Antibody (C-term) Cat.-No AP52005PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

HAX1 - human gene knockout kit via CRISPR

HAX1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HAX1 - human gene knockout kit via CRISPR

HAX1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HAX1 - human gene knockout kit via CRISPR

HAX1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HAX1 - human gene knockout kit via CRISPR

HAX1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hax1 - mouse gene knockout kit via CRISPR

Hax1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hax1 - mouse gene knockout kit via CRISPR

Hax1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hax1 - mouse gene knockout kit via CRISPR

Hax1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hax1 - mouse gene knockout kit via CRISPR

Hax1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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