HCN1 / BCNG1 antibody

Principal name

HCN1 / BCNG1 antibody

Alternative names for HCN1 / BCNG1 antibody

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1

SwissProt ID

O60741 (Human), O88704 (Mouse), Q9JKB0 (Rat), Q9MZS1 (Rabit)

Gene ID

348980 (HCN1), 84390 (Hcn1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Sheep, Mouse, Rat

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of HCN1 / BCNG1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifically, hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HCN1 / BCNG1 antibody

Predicted band size: 99 kDa . Positive control: Human brain malignant glioma and mouse brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lane1: Human brain malignant glioma tissue lysate Lane2: Mouse brain tissue lysate Lysates: 40 ug per lane Primary antibody: 1/1500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HCN1 / BCNG1 antibody

Predicted band size: 99 kDa . Positive control: Hela cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/950 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HCN1 / BCNG1 antibody

Western blot analysis of HCN1 in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S70-28 Purified Hu, Ms, Rt C, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HCN1 / BCNG1 antibody

Western blot analysis of extracts of various cell lines, using HCN1 antibody. (1:U251  2: mouse brain tissue lysate) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HCN1 / BCNG1 antibody

Western blot analysis of rat brain membrane: 1. Anti-HCN1 antibody , (1:200). 2. Anti-HCN1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

HCN1 / BCNG1 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N70/28 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

HCN1 / BCNG1 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N70/28 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

HCN1 / BCNG1 antibody

HCN1 / BCNG1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

HCN1 / BCNG1 antibody

HCN1 / BCNG1 Rabbit Serum Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

HCN1 / BCNG1 antibody

HCN1 / BCNG1 Sheep Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

HCN1 / BCNG1 antibody

Immunohistochemistry: HCN1 Antibody(S70-28) [NBP1-22450]- Human Hippocampus Mouse IgG1 S70-28 Purified Hu, Ms, Rt C, IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

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