HCN2 / BCNG2 antibody

Principal name

HCN2 / BCNG2 antibody

Alternative names for HCN2 / BCNG2 antibody

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Brain cyclic nucleotide-gated channel 2

SwissProt ID

O88703 (Mouse), Q9JKA9 (Rat), Q9UL51 (Human)

Gene ID

114244 (Hcn2), 610 (HCN2)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of HCN2 / BCNG2 antibody

Hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient . Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical sigls, temperature, or mechanical forces.There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and filly those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and ictivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Filly, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels . Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain .

General readings

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd
Ed., Sinauer Associated Inc.:Sunderland, MA USA.
2. www.iochannels.org
3. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HCN2 / BCNG2 antibody

Western blot analysis of rat brain membranes: 1. Anti-HCN2 antibody, (1:200). 2. Anti-HCN2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

HCN2 / BCNG2 antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and ovarian cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human breast and ovarian cancer tissue using HCN2 antibody at dilution 1/80, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HCN2 / BCNG2 antibody

IF analysis of HCN2 in human hippocampal tissues using the antibody Mouse IgG1 S71-37 Purified Ms, Rt C, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HCN2 / BCNG2 antibody

Upper right: Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and of COS-1 cells transfected with GFPHCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N71/37 (left), K89/34 (middle) or a control (right) TC supe. Mouse IgG1 N71/37 Supernatant Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

HCN2 / BCNG2 antibody

Upper right: Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and of COS-1 cells transfected with GFPHCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N71/37 (left), K89/34 (middle) or a control (right) TC supe. Mouse IgG1 N71/37 Purified Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

HCN2 / BCNG2 antibody

Western blot (WB) analysis of HCN2 antibody (Cat.-No.: AP01496PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HCN2 / BCNG2 antibody

HCN2 / BCNG2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

HCN2 / BCNG2 antibody

Western blot analysis of extracts from Jurkat cells, using HCN2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

HCN2 / BCNG2 antibody

Western blot analysis of extracts from Jurkat cells, using HCN2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

HCN2 / BCNG2 antibody

Western Blot: HCN2 Antibody [NBP1-00866] - Western blot (WB) analysis of HCN2 (E521) antibody in extracts from Jurkat cells Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Novus Biologicals Inc.

HCN2 / BCNG2 antibody

HCN2 / BCNG2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

HCN2 / BCNG2 antibody

HCN2 / BCNG2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  Novus Biologicals Inc.

Lysates (Overexpressed)

Catalog No.    

HCN2 overexpression lysate

HCN2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

13 Item(s)

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