HCN4 antibody

Principal name

HCN4 antibody

Alternative names for HCN4 antibody

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

SwissProt ID

O70507 (Mouse), Q9JKA7 (Rat), Q9TV66 (Rabit), Q9Y3Q4 (Human)

Gene ID

10021 (HCN4), 59266 (Hcn4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Rat, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of HCN4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HCN4 antibody

Western blot analysis of HCN4 in T-HEK cells using a 1:1000 dilution of the antibody Mouse IgG1 S114-10 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HCN4 antibody

Western blot analysis of rat brain membranes: 1. Anti-HCN4 antibody , (1:200). 2. Anti-HCN4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

HCN4 antibody

Adult rat thalamus immunohistochemistry Mouse IgG1 N114/10 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

HCN4 antibody

Adult rat thalamus immunohistochemistry Mouse IgG1 N114/10 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

HCN4 antibody

HCN4 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

HCN4 antibody

HCN4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

HCN4 antibody

HCN4 Mouse IgG2a 2A5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HCN4 antibody

HCN4 Rat IgG1 SHG 1E5 Ascites Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

HCN4 antibody

HCN4 Rabbit Serum Hu WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HCN4

HCN4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

HCN4

HCN4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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