HCV Core protein antibody

Principal name

HCV Core protein antibody

Alternative names for HCV Core protein antibody

Hepatitis C Virus core protein

Available reactivities

Hu (Human), Vi (Virus)

Available hosts

Mouse, Rabbit, Goat

Available applications

Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))

Background of HCV Core protein antibody

The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication.
Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.

General readings

General / background references:Bergqvist A et al. The hepatitis C virus core protein modulates T cell responses by inducing spontaneous and altering T-cell receptor-triggered Ca2+ oscillations. J Biol Chem 278:18877-83 (2003). PubMed PMID: 12639962
Bergqvist A & Rice CM Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein. J Virol 75:772-81 (2001). PubMed PMID: 11134290
Moradpour D et al. Characterization of three novel monoclonal antibodies against hepatitis C virus core protein. J Med Virol 48:234-41 (1996). PubMed PMID: 8801283

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HCV Core protein (1-80) antibody

HCV Core protein Mouse IgG2a 6A1 Purified E
0.1 mg / €400.00
  Acris Antibodies GmbH

HCV Core protein (1-80) antibody

HCV Core protein Mouse IgG2a 6A1 Biotin E
0.1 mg / €430.00
  Acris Antibodies GmbH

HCV Core protein (1-80) antibody

HCV Core protein Mouse IgG2a 6A1 FITC C, E, ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

HCV Core protein Genotype 1a+2 antibody

HCV Core protein Mouse IgG1 B057M Purified E, ICC/IF, WB
1 mg / €810.00
  Acris Antibodies GmbH

HCV Core protein Genotype 1a+2 antibody

HCV Core protein Mouse IgG1 B056M Purified E, ICC/IF
1 mg / €810.00
  Acris Antibodies GmbH

HCV Core protein Genotype 1a+2 antibody

HCV Core protein Mouse IgG2a B055M Purified E
1 mg / €810.00
  Acris Antibodies GmbH

HCV Core protein (2-192) antibody

HCV Core protein Mouse IgG1 1H7 Supernatant E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

HCV Core protein (33-38) antibody

HCV Core protein Mouse IgG1 B317M Purified C, E, ICC/IF, WB
1 mg / €810.00
  Acris Antibodies GmbH

HCV Core protein (33-38) antibody

HCV Core protein Mouse IgG1 1868 Purified E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

HCV Core protein antibody

HCV Core protein Mouse IgG1 A1/3D1 Aff - Purified Hu E
0.5 mg / €430.00
  Acris Antibodies GmbH

HCV Core protein antibody

HCV Core protein Mouse IgG1 B2 Aff - Purified Hu E, WB
0.5 mg / €450.00
  Acris Antibodies GmbH

HCV Core protein antibody

HCV Core protein Mouse IgG1 C3 Aff - Purified Hu E, WB
0.5 mg / €430.00
  Acris Antibodies GmbH

HCV Core protein (1-120) antibody

HCV Core protein Goat Purified E, WB
1 ml / €440.00
  Acris Antibodies GmbH

HCV Core protein (1-61) antibody

HCV Core protein Mouse IgG1 1851 Purified C, E, WB
0.1 mg / €1,460.00
  Acris Antibodies GmbH

HCV Core protein (80-160) antibody

HCV Core protein Mouse IgG2a 7A1 Purified E
0.1 mg / €350.00
  Acris Antibodies GmbH

HCV Core protein (80-160) antibody

HCV Core protein Mouse IgG2a 7A1 Biotin E, F, ICC/IF
0.1 mg / €400.00
  Acris Antibodies GmbH

HCV Core protein (80-160) antibody

HCV Core protein Mouse IgG2a 7A1 FITC ICC/IF
0.1 mg / €400.00
  Acris Antibodies GmbH

HCV Core protein (2-192) antibody

HCV Core protein Mouse IgG2a 8A4 Purified E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

HCV Core protein (70-90) antibody

HCV Core protein Mouse IgG1 11-B3 Purified C, E, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

HCV Core protein antibody

HCV Core protein Mouse IgG2a 1-E-5 E, IP
0.1 mg / €560.00
  Abnova Taiwan Corp.

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