HCV Envelope glycoprotein E1 antibody

Principal name

HCV Envelope glycoprotein E1 antibody

Alternative names for HCV Envelope glycoprotein E1 antibody

Heptitis C Virus E1, gp32, gp35

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of HCV Envelope glycoprotein E1 antibody

Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HCV Envelope glycoprotein E1 antibody

HCV Envelope glycoprotein E1 Mouse IgG BDI198 Purified C, E, ICC/IF, WB
1 mg / €560.00
  Acris Antibodies GmbH

HCV Envelope glycoprotein E1 antibody

HCV Envelope glycoprotein E1 Mouse IgG1 1879 Purified E
0.1 mg / €360.00
  Acris Antibodies GmbH

HCV Envelope glycoprotein E1 antibody

HCV Envelope glycoprotein E1 Rabbit E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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