HDAC1 antibody

Principal name

HDAC1 antibody

Alternative names for HDAC1 antibody

Histone deacetylase 1, HD1, RPD3L1

SwissProt ID

O09106 (Mouse), P56517 (Chick), Q13547 (Human), Q32PJ8 (Bovin), Q4QQW4 (Rat), Q8JIY7

Gene ID

3065 (HDAC1), 7192302 (gcvH), 433759 (Hdac1)

Available reactivities

Can (Canine), Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Dros (Drosophila), Chk (Chicken), Chimp (Chimpanzee), Ze (Zebrafish), African clawed frog, Por (Porcine), Rb (Rabbit), Mky (Monkey), Xen (Xenopus)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), PLA/Proximity ligation assay (PLA), Enzyme Immunoassay (E), Flow Cytometry (F), ChIP assay (ChIP), ELISA (detection) (E(detection))

Background of HDAC1 antibody

Chromatin is composed of basic repeating units called nucleosomes, which are 146 bp of DNA wound around a histone octamer composed of two each of the core histones H2A, H2B, H3 and H4. Reversible acetylation of highly conserved lysine residues in N-terminal tail domains of core histones plays an important role in transcriptional regulation, cell cycle progression and developmental events. Several histone acetyltransferases (HATs) catalyze the acetylation reaction (GCN5, PCAF, p300/CBP, TAFII250, P/CAF, SRC-1 BRCA-2). Acetylation of the core histones is generally considered to be associated with gene activation, probably through maintenance of the unfolded structure of transcribing nucleosomes. Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Both activities are associated with the nuclear matrix. Six or seven different mammalian HDACs have been described. HDACs are similar to the yeast Rpd3 protein, while HDACs are similar to the yeast Hda1 protein. Histone deacetylase activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. HDAC1 and 2 are the catalytic subunits of different multiprotein regulatory complexes. The components of such complexes include: corepressors such as mSin3, N-CoR, SMRT, associated proteins such as SAP18, SAP30, RbAp46, RbAp48, c-Ski oncogenic protein, a protein involved in DNA methylation, and more.

General readings

1.Taunton J, Hassig CA, Schreiber SL (May 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p".

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HDAC1 (466-482) antibody

Western Blot of Rabbit Anti-HDAC-1 Antibody. Lane 1: LNCaP prostate cancer cells. Lane 2: none. Load: 50 µg per lane. Primary antibody: HDAC-1 antibody at 1:1000 for overnight at 4°C. Secondary antibody: IRDye800™ rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 55kDa for HDAC-1. Other band(s): none. Rabbit IgG Aff - Purified Bov, Chimp, Chk, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC1 antibody

Western blot analysis of extracts of various cell lines, using HDAC1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC1 antibody

Anti-HDAC1 mouse monoclonal antibody (TA502142) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC1(RC201745). Mouse IgG2b OTI5C3 Purified Hu, Mky, Rt F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC1 antibody

Anti-HDAC1 mouse monoclonal antibody (TA502193) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC1(RC201745). Mouse IgG2b OTI5F9 Purified Can, Hu, Mky, Ms, Rt F, ICC/IF, WB
0.1 ml / €248.00
  OriGene Technologies, Inc.

TrueMAB

HDAC1 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3E1 Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

HDAC1 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1D6 Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

HDAC1 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 5A11 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

HDAC1 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 5C11 Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

HDAC1 (271-477) antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

HDAC1 antibody

Immunoperoxidase of monoclonal antibody to HDAC1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG1 3E1 Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HDAC1 antibody

Immunoperoxidase of monoclonal antibody to HDAC1 on formalin-fixed paraffin-embedded human liver. [antibody concentration 3 ug/ml] Mouse IgG1 1D6 Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HDAC1 antibody

Immunoperoxidase of monoclonal antibody to HDAC1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 0.7 ug/ml] Mouse IgG2a 5A11 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HDAC1 antibody

Immunoperoxidase of monoclonal antibody to HDAC1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Mouse IgG1 5C11 Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HDAC1 antibody

Human Heart; . Rabbit Anti-HDAC1 antibody. . Catalog Number:. ARP32358_P050 . Paraffin Embedded Tissue: Human Heart cell . Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; HDAC1 antibody (ARP32358_P050) in Human Heart cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Dros, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

HDAC1 antibody

Immunohistochemistry-Paraffin: HDAC1 Antibody [NBP1-78101] - 1 by immunohistochemistry in human prostate cancer tissue. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €510.00
  Novus Biologicals Inc.

HDAC1 antibody

AP15592PU HDAC1 antibody staining of Human Tonsil. Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

HDAC1 antibody

AP15592PU HDAC1 antibody staining of Human Tonsil. Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €440.00
  Acris Antibodies GmbH

HDAC1 antibody

AP15592PU HDAC1 antibody staining of Human Tonsil. Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

HDAC1 antibody

Western blot analysis of extracts from NIH/3T3 cells, and 293 cells treated with LiCl (10nM, 30mins), using HDAC1 (Ab-421) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC1 antibody

Western blot analysis of extracts from NIH/3T3 cells, using HDAC1 antibody (#TA312925).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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