HDAC11 antibody

Principal name

HDAC11 antibody

Alternative names for HDAC11 antibody

Histone deacetylase 11, HD11

SwissProt ID

Q91WA3 (Mouse), Q96DB2 (Human)

Gene ID

79885 (HDAC11), 232232 (Hdac11)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Dros (Drosophila), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of HDAC11 antibody

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years. These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-termil regions, except that HDAC-6 contains two copies of the domain, one within each of the N-termil and C-termil regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. Recently, a new member of this family, HDAC11, has been cloned by Gao et al. HDAC11 transcripts were limited to kidney, heart, brain, skeletal muscle, and testis. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

General readings

Janssen, C., et al. J. Neuropathol. Exp. Neurol. 69(6):573-581(2010)
Glozak, M.A., et al. J. Biol. Chem. 284(17):11446-11453(2009)
Georgopoulos, K. Nat. Immunol. 10(1):13-14(2009)
Villagra, A., et al. Nat. Immunol. 10(1):92-100(2009)
Fournel, M., et al. Mol. Cancer Ther. 7(4):759-768(2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HDAC11 antibody

  Rabbit Polyclonal HDAC11 Antibody  
Western Blot: HDAC11 Antibody [TA336345] - Western blot analysis of HDAC11 using HDAC11 antibody. Brain lysate from (A) human, (B) mouse and © rat brain probed with HDAC11 antibody at 2 ug/ml. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC11 antibody

  HDAC11 mouse monoclonal antibody, clone OTI7H10 (formerly 7H10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HDAC11 (RC201919, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HDAC11. Mouse IgG1 OTI7H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC11 antibody

  HDAC11 mouse monoclonal antibody, clone OTI7A7 (formerly 7A7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HDAC11 (RC201919, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HDAC11. Mouse IgG1 OTI7A7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC11 antibody

  HDAC11 mouse monoclonal antibody, clone OTI2G5 (formerly 2G5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HDAC11 (RC201919, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HDAC11. Mouse IgG1 OTI2G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC11 antibody

  HDAC11 mouse monoclonal antibody, clone OTI7D2 (formerly 7D2)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HDAC11 (RC201919, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HDAC11. Mouse IgG1 OTI7D2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC11 antibody

  HDAC11 mouse monoclonal antibody, clone OTI1D5 (formerly 1D5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HDAC11 (RC201919, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HDAC11. Mouse IgG1 OTI1D5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC11 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HDAC11 (C-term) antibody

(LEFT) Purified rabbit anti-HDAC11 antibody (C-term) (Cat.#AP11143PU-N) was used in immunohistochemistry on Breast Carcinoma. (RIGHT) Formalin-fixed and paraffin-embedded human testicle tumor tissue reacted with HDAC11 antibody (C-term) (Cat.#AP11143PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HDAC11 (Center) antibody

Western blot analysis of HDAC11 Antibody (Center) Cat.-No AP52023PU-N in mouse testis tissue lysates (35ug/lane). This demonstrates the HDAC11 antibody detected the HDAC11 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

HDAC11 - human gene knockout kit via CRISPR

HDAC11 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HDAC11 - human gene knockout kit via CRISPR

HDAC11 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HDAC11 - human gene knockout kit via CRISPR

HDAC11 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HDAC11 - human gene knockout kit via CRISPR

HDAC11 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hdac11 - mouse gene knockout kit via CRISPR

Hdac11 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hdac11 - mouse gene knockout kit via CRISPR

Hdac11 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hdac11 - mouse gene knockout kit via CRISPR

Hdac11 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hdac11 - mouse gene knockout kit via CRISPR

Hdac11 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HDAC11 (transcript variant 2)

  Recombinant protein of human histone deacetylase 11 (HDAC11), transcript variant 2  
HDAC11 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

HDAC11 overexpression lysate

HDAC11 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HDAC11 (mGFP-tagged) - Human histone deacetylase 11 (HDAC11), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC11 (mGFP-tagged) - Human histone deacetylase 11 (HDAC11), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €920.00
  OriGene Technologies, Inc.

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