HDAC2 antibody

Principal name

HDAC2 antibody

Alternative names for HDAC2 antibody

Histone deacetylase 2, HD2

SwissProt ID

P56519 (Chick), P70288 (Mouse), Q92769 (Human)

Gene ID

3066 (HDAC2), 15182 (Hdac2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), African clawed frog, Can (Canine), Hst (Hamster), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), ChIP assay (ChIP)

Background of HDAC2 antibody

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to D. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents.HDAC1 and HDAC2 are highly homologous and are involved in histone deacetylation, chromatin remodeling and transcriptiol repression. Both proteins are found together in numerous complexes including the nucleosome remodeling and deacetylation complex (NuRD), MeCP1, and the mSin3A corepressor complex.

General readings

Ishikawa, F., et al. Oncogene 29(6):909-919(2010)
Bush, E.W., et al. Circ. Res. 106(2):272-284(2010)
Krishnan, M., et al. Oncogene 29(2):305-312(2010)
Lehmann, A., et al. BMC Cancer 9, 395 (2009)
Hassig, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 95(7):3519-3524(1998)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HDAC2 antibody

  Rabbit Polyclonal HDAC2 Antibody  
Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-HDAC2 rabbit polyclonal antibody. (TA590734) Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  HDAC2 mouse monoclonal antibody, clone OTI7E10 (formerly 7E10)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-HDAC2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808327)(1:150) Mouse IgG1 OTI7E10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC2 pSer394 antibody

Figure 1. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using HDAC2 (pSer394) antibody AP08014PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

HDAC2 pSer394 antibody

Figure 1. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using HDAC2 (pSer394) antibody AP08014PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

HDAC2 antibody

  Rabbit anti-HDAC2 (Phospho-Ser394) polyclonal antibody(Phospho-specific)  
Western blot analysis of extracts from HT29 cells untreated or treated with UV, using HDAC2 antibody (Lanes 1 and 2) and HDAC2 (phospho-Ser394) antibody (Lanes 3 and 4). Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit polyclonal HDAC2 (Ab-394) antibody  
Western blot analysis of extracts from HepG2 cells, using HDAC2 (Ab-394) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit polyclonal HDAC2 (Ser394) antibody(Phospho-specific)  
Western blot analysis of extracts from 293 cells, COS cells and HeLa cells, all treated with PMA (125ng/ml, 30mins), using HDAC2 (Phospho-Ser394) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Anti-HDAC2 Rabbit Polyclonal Antibody  
Predicted band size: 55 kDa . Positive control: 293 and Hela cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1: 293 cells lysate Lane2: Hela cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Anti-HDAC2 Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human breast and colon cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human breast and colon cancer tissue using HDAC2 antibody at dilution 1/17, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Anti-HDAC2 Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human ovarian and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human ovarian and colon cancer tissue using HDAC2 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 (Center) antibody

  Rabbit polyclonal HDAC2 Antibody (Center)  
HDAC2 Antibody (Center) (Cat. #TA325112) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the HDAC2 antibody detected the HDAC2 protein (arrow). Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit Polyclonal HDAC2 Antibody  
Western blot analysis of HDAC2 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit Polyclonal HDAC2 (Ser394) Antibody (Phospho-specific)  
HDAC2 Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  HDAC2 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using HDAC2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Mouse monoclonal anti-HDAC2 antibody (Center)  
HDAC2 Antibody (Center) (Cat.# TA328156) western blot analysis in Hela cell lysate (35ug/lane). This demonstrates that the HDAC2 antibody detected HDAC2 protein (arrow). Mouse IgG1 1194CT18.5.1 Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit Polyclonal Anti-HDAC2 Antibody  
WB Suggested Anti-HDAC2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Hu ChIP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit Polyclonal Anti-HDAC2 Antibody  
Host:Rabbit; Target Name:HDAC2; Sample Tissue:Human Adult Placenta; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Mouse Monoclonal HDAC2 Antibody  
WB using the antibody against HDAC2 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right (expected size: 55 kDa); the marker (in kDa) is shown on the left. Mouse IgG1 Monoclol Purified Hu
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit Polyclonal Anti-HDAC2 Antibody  
Western blot analysis of HDAC2 in HeLa cell lysate with HDAC2 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC2 antibody

  Rabbit Polyclonal anti-HDAC2 Antibody  
Western Blot analysis of K562 cell lysate with HDAC-2 antibody Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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