HDAC6 antibody

Principal name

HDAC6 antibody

Alternative names for HDAC6 antibody

Histone deacetylase 6, HD6, KIAA0901, JM21

SwissProt ID

Q9UBN7 (Human), Q9Z2V5 (Mouse)

Gene ID

10013 (HDAC6), 15185 (Hdac6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Mky (Monkey), Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ChIP assay (ChIP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of HDAC6 antibody

Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Class 1 HDACs are predominantly nuclear while class 2 HDACs shuttle between the nucleus and cytosol. HDAC6 is a class 2 histone deacetylase enzyme localized to the cytoplasm and associated with the microtubule network. It is involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 contains two tandem catalytic domains that facilitate the deacetylation of multiple protein substrates, including histones and non-histone proteins such as tubulin, cortactin, and HSP90. In addition to its role as a protein deacetylase, HDAC6 functions as a component of the aggresome, a inclusion body that forms in response to an accumulation of misfolded or partially denatured proteins. Formation of the aggresome is a protective response that sequesters cytotoxic protein aggregates for eventual autophagic clearance from the cell. HDAC6 contains a zinc finger ubiquitin-binding domain that binds both mono- and poly-ubiquitinated proteins. It facilitates the transport of misfolded proteins to the aggresome. HDAC6 is also required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Thus, HDAC6 plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases, such as neurodegenerative Huntington’s disease.
Structure: 1215 amino acids with predicted molecular weight of 130 kD. 
Distribution: Nucleus, Cytoplasm.
Function:
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). In addition to its protein deacetylase activity, also plays a key role in the degradation of misfolded proteins
Interaction: Interacts with CBFA2T3, HDAC11, and SIRT2; Interacts with F-actin; Interacts with BBIP10; Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions.

General readings

Int J Mol Med. 2003 Jul;12(1):87-93.

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  2. Highly Validated (8)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HDAC6 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-HDAC6 mouse monoclonal antibody (TA502030) at 1:150 dilution. Mouse IgG1 OTI4C5 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 antibody

Anti-HDAC6 mouse monoclonal antibody (TA502000) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC6(RC209649). Mouse IgG1 OTI1D10 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-HDAC6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502001) Mouse IgG1 OTI1B3 Purified Hu, Mky F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 antibody

Anti-HDAC6 mouse monoclonal antibody (TA502053) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC6(RC209649). Mouse IgG1 OTI1D11 Purified Can, Hu, Mky, Rt F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HDAC6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502082) Mouse IgG1 OTI5E6 Purified Hu, Mky F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 antibody

Anti-HDAC6 mouse monoclonal antibody (TA502083) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC6(RC209649). Mouse IgG1 OTI3G7 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-HDAC6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502177) Mouse IgG1 OTI3E7 Purified Hu, Mky F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 (N-term) antibody

Human Intestine, Ganglion Cells: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

HDAC6 antibody

Immunocytochemistry: HDAC6 Antibody - HDAC-6 antibody was tested in HeLa cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 594 (red). Rabbit Purified Hu C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western blot analysis of extracts from HeLa cells, using HDAC6 antibody (#TA312294).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western blot analysis of HDAC6 expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC6 (C-term) antibody

TA326313 (1µg/ml) staining of HeLa nuclear lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western blot analysis of extracts of various cell lines, using HDAC6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western Blot: HDAC6 Antibody [TA336337] - analysis of HDAC-6 in NIH 3T3 cell lysate with this antibody. Rabbit Purified Hu, Ms ChIP, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

WB Suggested Anti-Hdac6 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Testis Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt ChIP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western blot analysis on NIH-3T3 cell lysate using HDAC6 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western blot analysis of HDAC6 expression in HepG2 cell lysate Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Western blot analysis of HDAC6 in human testis tissue lysate with HDAC6 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC6 antibody

Anti-HDAC6 mouse monoclonal antibody (TA502222) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC6(RC209649). Mouse IgG1 OTI3F9 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HDAC6 (1-180) antibody

293 total cell lysates were resolved by eletrophoresis, transferred to nitrocellulose, and probed with monoclonal anti-HDAC6 Antibody Cat.-No AM33067PU-N (clone 18E2SC). Proteins were visualized using a HRP conjugated goat anti-mouse antibody and a chemiluminescence detection system. Mouse IgG1 18E2SC Purified Hu WB
0.1 mg / €420.00
  Acris Antibodies GmbH

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