HDAC8 antibody

Principal name

HDAC8 antibody

Alternative names for HDAC8 antibody

Histone deacetylase 8, HD8, HDACL1, CDA07

SwissProt ID

Q8VH37 (Mouse), Q9BY41 (Human)

Gene ID

55869 (HDAC8), 70315 (Hdac8)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Can (Canine), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP)

Background of HDAC8 antibody

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

General readings

Hu E., et al. (2000) J. Biol. Chem. 275:15254-15264Buggy J.J., et al. (2000) Biochem. J. 350:199-205

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HDAC8 antibody

  Rabbit anti-HDAC8 (Phospho-Ser39) polyclonal antibody(Phospho-specific)  
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using HDAC8 (phospho-Ser39) antibody. Rabbit IgG Purified Hu, Ms, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit anti-HDAC8 polyclonal antibody  
Western blot analysis of extracts from NIH/3T3 cells using HDAC8 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit polyclonal anti-HDAC8 antibody  
Western blot analysis of HDAC8 with human Jurkat cell lysates Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit polyclonal anti-HDAC8 antibody  
Western blot analysis using recombinant human HDAC8. Lane 1: 30 ng, Lane 2: 60 ng, Lane 3: 120 ng, Lane 4: 250 ng. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit Polyclonal HDAC8 Antibody  
Western blot analysis of HDAC8 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit Polyclonal HDAC8 (Ser39) Antibody (Phospho-specific)  
Western blot analysis of HDAC8 phosphorylation expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit anti-HDAC8 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using HDAC8 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Phospho-HDAC8-S39 Rabbit Polyclonal Antibody  
HDAC8 Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit Polyclonal Anti-HDAC8 Antibody  
WB Suggested Anti-HDAC8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit Polyclonal Anti-HDAC8 Antibody  
WB Suggested Anti-HDAC8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

  Rabbit Polyclonal Anti-HDAC8 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: 293T cells, Primary antibody: (HDAC8 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC8 pSer39 antibody

HDAC8 Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HDAC8 antibody

Immunohistochemistry (IHC) analyzes of HDAC8 antibody (Cat.-No.: AP06162PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HDAC8 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HDAC8 pSer39 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using HDAC8 (Phospho-Ser39) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €230.00
  Assay Biotech

HDAC8 pSer39 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using HDAC8 (Phospho-Ser39) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €330.00
  Assay Biotech

HDAC8 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HDAC8 (Ab-39) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

HDAC8 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HDAC8 (Ab-39) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Hdac8 - mouse gene knockout kit via CRISPR

Hdac8 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hdac8 - mouse gene knockout kit via CRISPR

Hdac8 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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