HDAC8 antibody

Principal name

HDAC8 antibody

Alternative names for HDAC8 antibody

Histone deacetylase 8, HD8, HDACL1, CDA07

SwissProt ID

Q8VH37 (Mouse), Q9BY41 (Human)

Gene ID

55869 (HDAC8), 70315 (Hdac8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Ze (Zebrafish), African clawed frog, Can (Canine), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of HDAC8 antibody

Regulation of gene expression is mediated by several mechanisms such as DNA methylation, ATP-dependent chromatin remodeling, and post translational modifications of histones, which include the dynamic acetylation and deacetylation of epsilon-amino groups of lysine residues present in the tail of core histones. The enzymes responsible for reversible acetylation/deacetylation processes are histone acetyltransferases(HATs) and histone deacetylases (HDACs), respectively. HATs act as transcriptional coactivators, and HDACs are part of transcriptional corepressor complexes. Mammalian HDACs can be divided into three classes according to sequence homology. Class I consists of the yeast Rpd3-like proteins (HDAC1, HDAC2, HDAC3, and HDAC8). Class II consists of the yeast Hda1-like proteins (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10). Class III comprises the yeast Sir2-like proteins. Class I HDACs are ubiquitously expressed, and most class II HDACs are tissue-specific. Class II HDACs have been implicated in the regulation of muscle differentiation. Interaction of HDAC4, 5, and 7 with members of the MEF2 family of transcription factors represses their transcriptional activity and prevents myogenesis. The deacetylase activity of class II HDACs is regulated by subcellular localization. The HDAC8 gene encodes for a 377 amino acid protein with a molecular weight of 43 kDa and is localized within the nucleus. HDAC8 mRNA is expressed in heart, lung, kidney, and pancreas as well as in several cell lines derived from cancer tissues.

General readings

Hu E., et al. (2000) J. Biol. Chem. 275:15254-15264Buggy J.J., et al. (2000) Biochem. J. 350:199-205

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HDAC8 antibody

Immunofluorescence of monoclonal antibody to HDAC8 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2b 2F4 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HDAC8 antibody

Western blot analysis of extracts from NIH/3T3 cells using HDAC8 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

Western blot analysis of HDAC8 with human Jurkat cell lysates Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

Western blot analysis using recombinant human HDAC8. Lane 1: 30 ng, Lane 2: 60 ng, Lane 3: 120 ng, Lane 4: 250 ng. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

Western blot analysis of HDAC8 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

Western blot analysis of extracts of various cell lines, using HDAC8 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

WB Suggested Anti-HDAC8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC8 antibody

WB Suggested Anti-HDAC8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

HDAC8 control peptide

HDAC8 Purified
50 µg / €190.00
  Acris Antibodies GmbH

HDAC8 pSer39 antibody

HDAC8 Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HDAC8 antibody

Immunohistochemistry (IHC) analyzes of HDAC8 antibody (Cat.-No.: AP06162PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HDAC8 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HDAC8 antibody

Immunofluorescence of purified MaxPab antibody to HDAC8 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

HDAC8 antibody

HDAC8 Mouse Hu ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

HDAC8 antibody

Immunoprecipitation of HDAC8 transfected lysate using anti-HDAC8 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with HDAC8 MaxPab mouse polyclonal antibody (B01) (H00055869-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

HDAC8 antibody

Western Blot analysis of HDAC8 expression in transfected 293T cell line (H00055869-T01) by HDAC8 MaxPab polyclonal antibody.

Lane 1: HDAC8 transfected lysate(41.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HDAC8 antibody

HDAC8 Mouse IgG2a 2F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HDAC8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the HDAC8 polyclonal antibody ( Cat # PAB2336 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

HDAC8 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HDAC8 polyclonal antibody ( Cat # PAB5387 ) . Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

HDAC8 antibody

Western blot analysis of Hdac8 with human Jurkat cell lysates. The antibody recognizes 78 kDa and 42 kDa Hdac8 of human, mouse, and rat origins. Rabbit Hu, Ms, Rt C, IP, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

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