HDAC8 antibody
Principal name
HDAC8 antibody
Alternative names for HDAC8 antibody
Histone deacetylase 8, HD8, HDACL1, CDA07
Ncbi ID
NP_001159890.1, 9606, NP_060956, 10090, NP_060956.1, NM_018486, NM_001166418, NP_081658.1, NM_027382, NM_001166448, NM_001166420, NM_001166419
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP)
Background of HDAC8 antibody
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
General readings
Hu E., et al. (2000) J. Biol. Chem. 275:15254-15264Buggy J.J., et al. (2000) Biochem. J. 350:199-205






























Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
---|---|---|---|---|---|---|---|
TA337234 | HDAC8 antibody |
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Rabbit Polyclonal Anti-HDAC8 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Rb, Rt | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. | |||||||
TA337235 | HDAC8 antibody |
||||||
Rabbit Polyclonal Anti-HDAC8 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. |