HDAC8 antibody

Principal name

HDAC8 antibody

Alternative names for HDAC8 antibody

Histone deacetylase 8, HD8, HDACL1, CDA07

SwissProt ID

Q8VH37 (Mouse), Q9BY41 (Human)

Gene ID

55869 (HDAC8), 70315 (Hdac8)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Can (Canine), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP)

Background of HDAC8 antibody

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

General readings

Hu E., et al. (2000) J. Biol. Chem. 275:15254-15264Buggy J.J., et al. (2000) Biochem. J. 350:199-205

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CRISPR

Catalog No. Species Donor Vector  

Hdac8 - mouse gene knockout kit via CRISPR

Hdac8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HDAC8 (N-term HIS tag, transcript variant 1)

  Purified recombinant protein of Human histone deacetylase 8 (HDAC8), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug  
HDAC8 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

HDAC8 (1-377, His-tag)

HDAC8 Human Purified > 80 % by SDS - PAGE SF9 cells
0.25 mg / €940.00
  Acris Antibodies GmbH

HDAC8 (1-377, His-tag)

HDAC8 Human Purified > 80 % by SDS - PAGE SF9 cells
50 µg / €370.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

HDAC8 overexpression lysate

HDAC8 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

HDAC8 overexpression lysate

HDAC8 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

HDAC8-knockout Cell lysate

HDAC8-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HDAC8 (mGFP-tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (mGFP-tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (mGFP-tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (mGFP-tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €989.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (mGFP-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (mGFP-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (mGFP-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (mGFP-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (mGFP-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 6, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (mGFP-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 6, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (Myc-DDK tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (Myc-DDK tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €969.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (Myc-DDK tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (Myc-DDK tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €886.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Lenti ORF particles, HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 6, 200 uL, >10^7 TU/mL

Lenti ORF particles, HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 6, 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hdac8 (GFP-tagged) - Mouse histone deacetylase 8 (Hdac8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hdac8 (GFP-tagged) - Mouse histone deacetylase 8 (Hdac8), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Hdac8 (Myc-DDK-tagged) - Mouse histone deacetylase 8 (Hdac8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hdac8 (Myc-DDK-tagged) - Mouse histone deacetylase 8 (Hdac8), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

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