Heat shock factor 1 / HSF1 antibody

Principal name

Heat shock factor 1 / HSF1 antibody

Alternative names for Heat shock factor 1 / HSF1 antibody

HSTF1, HSF-1, Heat shock transcription factor 1

SwissProt ID

P38529 (Chick), P38532 (Mouse), Q00613 (Human), Q08DJ8 (Bovin)

Gene ID

15499 (Hsf1), 3297 (HSF1)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Av (Birds)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Electrophoretic Mobility Shift Assay (EMSA), Frozen Sections (C)

Background of Heat shock factor 1 / HSF1 antibody

HSF1, or heat shock factor 1, belongs to a family of Heat Shock transcription factors that activate the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function (2). The up-regulation of HSP (heat shock proteins) expression by stressors is achieved at the level of transcription through a heat shock element (HSE) and a transcription factor (HSF) (3, 4, 5). Most HSFs have highly conserved amino acid sequences. On all HSFs there is a DNA binding domain at the Nterminus. Hydrophobic repeats located adjacent to this binding domain are essential for the formation of active trimers. Towards the C-terminal region another short hydrophobic repeat exists, and is thought to be necessary for suppression of trimerization (6).
There are two main heat shock factors, 1 and 2. Mouse HSF1 exists as two isoforms, however in higher eukaryotes HSF1 is found in a diffuse cytoplasmic and nuclear distribution in un-stressed cells. Once exposed to a multitude of stressors, it localizes to discrete nuclear granules within seconds. As it recovers from stress, HSF1 dissipates from these granules to a diffuse nuceloplasmic distribution. HSF2 on the other hand is similar to mouse HSF1, as it exists as two isoforms, the alpha form being more transciptionally active than the smaller beta form (7, 8). Various experiments have suggested that HFS2 may have roles in differentiation and development (9, 10, 11).

General readings

Wang,J., et al., (2006) J. Biol. Chem. 281 (5), 2451-2459

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Heat shock factor 1 / HSF1 antibody

  Rabbit polyclonal HSF1 (Ab-142) antibody  
Western blot analysis of extracts from K562 cells, using HSF1 (Ab-142) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Rabbit polyclonal HSF1 (Ab-121) antibody  
Western blot analysis of extracts from Jurkat cells, using HSF1 (Ab-121) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Rabbit polyclonal HSF1 (Thr142) antibody(Phospho-specific)  
Immunohistochemistry analysis of paraffin-embedded human brain tissue using HSF1 (Phospho-Thr142) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 (Sumoylation Site) antibody

  Rabbit polyclonal HSF1 Sumoylation Site Antibody  
HSF1 Antibody (Cat. #TA324718) western blot analysis in Jurkat cell line and mouse heart tissue lysates (35ug/lane).This demonstrates the HSF1 antibody detected the HSF1 protein (arrow). Rabbit Ig Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Rabbit Polyclonal HSF1 Antibody  
Western blot analysis of HSF1 expression in TNF-a treated MCF7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Rabbit Polyclonal HSF1 (Ser303) Antibody (Phospho-specific)  
Western blot analysis of HSF1 phosphorylation expression in TNF-a treated MCF7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Mouse monoclonal HSF1 Antibody  
HSF1 granules present in heat-shocked mitotic cells (green) detected by IF in mitotic heat shocked HeLa cells.  Courtesy of Morimoto Lab, Northwestern University, USA. Rat IgG1 10H8 Purified Bov, GP, Hst, Hu, Mky, Ms, Rb, Rt E, EMSA, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Phospho-HSF1-S303 Rabbit Polyclonal Antibody  
Heat shock factor 1 / HSF1 Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Phospho-HSF1-S307 Rabbit Polyclonal Antibody  
Heat shock factor 1 / HSF1 Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Rabbit Polyclonal Anti-HSF1 Antibody  
Western blot analysis on Jurkat cell lysate using HSF1 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

  Rabbit Polyclonal Anti-HSF1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using (HSF1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heat shock factor 1 / HSF1 antibody

Heat shock factor 1 / HSF1 Rat IgG1 4B4 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 antibody

Immunohistochemistry: AM03138PU-N HSF1 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate at 15 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 J7F9 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 antibody

Immunohistochemistry: AM03138PU-N HSF1 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate at 15 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 J7F9 Purified Hu E, P, WB
50 µl / €220.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 pSer303 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HSF1 antibody pSer303 Cat.-No. AP02511PU (Left) and the same antibody preincubated with blockig peptide (Right). Rabbit Aff - Purified Hu P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 pSer303 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HSF1 antibody pSer303 Cat.-No. AP02511PU (Left) and the same antibody preincubated with blockig peptide (Right). Rabbit Aff - Purified Hu P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using HSF1 antibody. Rabbit Aff - Purified Hu P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using HSF1 antibody. Rabbit Aff - Purified Hu P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HSF1 antibody. Rabbit Aff - Purified Hu P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Heat shock factor 1 / HSF1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HSF1 antibody. Rabbit Aff - Purified Hu P, WB
50 µl / €240.00
  Acris Antibodies GmbH

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