Helicobacter pylori antibody

Principal name

Helicobacter pylori antibody

Alternative names for Helicobacter pylori antibody

H. pylori

Available reactivities

Hu (Human), Bac (Bacteria), H. pylori (Helicobacter pylori)

Available hosts

Mouse, Rabbit, Goat, Chicken

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Helicobacter pylori antibody

Helicobacter pylori is a spiral shaped bacterium that lives in the stomach. It has a unique way of adapting to the harsh, acidic gastric environment. It has been studied rather extensively and believed by many in the medical community to play an important role in the development of gastritis and peptic ulcers. Consequently, there has been a fundamental shift in mainstream ulcer care from the widespread use of antacids (which temporarily alleviated some symptoms, but did nothing to address the root cause of the problem) to the "treatment" of gastritis and ulcers with potent antibiotics intended to kill H. pylori. H. pyloriproduces peptic ulcers by weakening the protective mucous coating of the stomach and duodenum, which allowed acid to get through to the sensitive lining beneath. Both the acid and the bacteria irritate the lining and cause a sore, or ulcer. H. pylori is able to survive in stomach acid because it secretes enzymes that neutralize the acid. This mechanism allows H. pylori to make its way to the "safe" area—the protective mucous lining. Once there, the bacterium¿s spiral shape helps it burrow through the lining. It is not clear why only a fraction of infected patients become symptomatic for the disease while others do not. It is believed that the bacteria are spread from individual to individual by fecal to oral or oral to oral route.
Several diagnostic tests for H pylori infection have been developed over the past several years, including breath test, blood and stool. Tissue test are done by taking a biopsy and examining the formation of urea produced by the bacteria, a culture or by actually staining the bacteria using antibodies to the bacteria coat proteins. It has a unique way of adapting to the harsh, acidic gastric environment. It has been studied rather extensively and believed by many in the medical community to play an important role in the development of gastritis and peptic ulcers. Consequently, there has been a fundamental shift in mainstream ulcer care from the widespread use of antacids (which temporarily alleviated some symptoms, but did nothing to address the root cause of the problem) to the "treatment" of gastritis and ulcers with potent antibiotics intended to kill H. pylori. H. pylori produces peptic ulcers by weakening the protective mucous coating of the stomach and duodenum, which allowed acid to get through to the sensitive lining beneath. Both the acid and the bacteria irritate the lining and cause a sore, or ulcer. H. pylori is able to survive in stomach acid because it secretes enzymes that neutralize the acid. This mechanism allows H. pylori to make its way to the "safe" area—the protective mucous lining. Once there, the bacterium¿s spiral shape helps it burrow through the lining. It is not clear why only a fraction of infected patients become symptomatic for the disease while others do not. It is believed that the bacteria are spread from individual to individual by fecal to oral or oral to oral route.
Several diagnostic tests for H pylori infection have been developed over the past several years, including breath test, blood and stool. Tissue test are done by taking a biopsy and examining the formation of urea produced by the bacteria, a culture or by actually staining the bacteria using antibodies to the bacteria coat proteins.
The binding of H pylori to MHC class II receptors in gastric epithelial cells led to increased activity of caspases and apoptosis (1). H pylori infections are also associated with iron deficiency and anemia. H pylori infection has been manifested in a number of vascular disorder including heart disease.

General readings

Kikuchi, Tohru, et al., (2002), Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappaB transcription factors, Journal of Antimicrobial Chemotherapy, 49, 745 - 755

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Helicobacter pylori antibody

Human H. pylori infected stomach tissue stained with anti-H pylori antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Human H. pylori infected stomach tissue stained with anti-H pylori antibody Rabbit Purified Hu P
1 ml / €490.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Human H. pylori infected stomach tissue stained with anti-H pylori antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Helicobacter pylori (19kDa OMP) antibody

Helicobacter pylori Mouse IgG1 BDI661 Purified E, ICC/IF, WB
1 mg / €680.00
  Acris Antibodies GmbH

Helicobacter pylori (19kDa OMP) antibody

Helicobacter pylori Mouse IgG1 BDI626 Purified E, ICC/IF, WB
1 mg / €710.00
  Acris Antibodies GmbH

Helicobacter pylori (54kDa Flagellin) antibody

Helicobacter pylori Mouse IgG1 BDI516 Purified E, ICC/IF, WB
1 mg / €710.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Helicobacter pylori Mouse IgG1 BGN/1203/939 Purified E
0.2 mg / €430.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Immunofluorescence staining of H. pylori in Paraffin Section of gastric biopsy sample. The Section was incubated with H. pylori  antibody Cat.-No AM02032PU followed by an appropriate secondary antibody coupled to Cy3. The nuclei were visualized with DAPI. Original magnification: x40 Mouse 3/15/45/2 Purified E, P
0.1 mg / €510.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Immunofluorescence staining of H. pylori in Paraffin Section of gastric biopsy sample. The Section was incubated with H. pylori  antibody Cat.-No AM02032PU followed by an appropriate secondary antibody coupled to Cy3. The nuclei were visualized with DAPI. Original magnification: x40 Mouse 3/15/45/2 Purified E, P
10 µg / €150.00
  Acris Antibodies GmbH

Helicobacter pylori (CagA Protein) antibody

Helicobacter pylori Mouse IgG2a 10E9 Aff - Purified E, E(capture), WB
0.5 mg / €450.00
  Acris Antibodies GmbH

Helicobacter pylori (CagA Protein) antibody

Helicobacter pylori Mouse IgG1 5H10 Aff - Purified E
0.5 mg / €430.00
  Acris Antibodies GmbH

Helicobacter pylori (CagA Protein) antibody

Helicobacter pylori Mouse IgG1 5C6 Aff - Purified E
0.5 mg / €430.00
  Acris Antibodies GmbH

Helicobacter pylori (CagA Protein) antibody

Helicobacter pylori Mouse IgG1 3C10 Aff - Purified E, E(detection)
0.5 mg / €450.00
  Acris Antibodies GmbH

Helicobacter pylori (CagA Protein) antibody

Helicobacter pylori Mouse IgG1 3C1 Aff - Purified E
0.5 mg / €430.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Helicobacter pylori Mouse IgG1 51-13 Purified H. pylori E, ICC/IF
1 ml / €260.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Helicobacter pylori Rabbit Serum E
0.1 ml / €500.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Helicobacter pylori Rabbit Serum E
20 µl / €180.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Immunofluorescence staining of H. pylori in Paraffin Section of gastric biopsy sample. The Section was incubated with H. pylori  antibody Cat.-No AM02034SU followed by an appropriate secondary antibody coupled to Cy3. The nuclei were visualized with DAPI. Original magnification: x40 Goat Serum E, P
0.1 ml / €440.00
  Acris Antibodies GmbH

Helicobacter pylori antibody

Immunofluorescence staining of H. pylori in Paraffin Section of gastric biopsy sample. The Section was incubated with H. pylori  antibody Cat.-No AM02034SU followed by an appropriate secondary antibody coupled to Cy3. The nuclei were visualized with DAPI. Original magnification: x40 Goat Serum E, P
20 µl / €170.00
  Acris Antibodies GmbH

Helicobacter pylori Control Peptide

Helicobacter pylori
0.25 mg / €250.00
  Acris Antibodies GmbH

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