Heme oxygenase 1 / HMOX1 antibody

Principal name

Heme oxygenase 1 / HMOX1 antibody

Alternative names for Heme oxygenase 1 / HMOX1 antibody

HO-1, HO, HO1

SwissProt ID

P06762 (Rat), P09601 (Human), P14791 (Chick), P14901 (Mouse), P32394 (Pig), Q5E9F2 (Bovin)

Gene ID

3162 (HMOX1), 24451 (Hmox1)

Available reactivities

Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Can (Canine), Mky (Monkey), Rb (Rabbit), GP (Guinea Pig), Sh (Sheep), Chk (Chicken), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Neutralisation (NEUT), ELISA (detection) (E(detection))

Background of Heme oxygenase 1 / HMOX1 antibody

Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs (2).
There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Upregulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).

General readings

Wu, M.M., et al. Toxicol. Appl. Pharmacol. 248(3):226-233(2010)
Bolisetty, S., et al. J. Am. Soc. Nephrol. 21(10):1702-1712(2010)
Bao, W., et al. PLoS ONE 5 (8), E12371 (2010)
Wu, M.M., et al. J. Biomed. Sci. 17, 70 (2010)
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Heme oxygenase 1 / HMOX1 antibody

Predicted cell location: Cytoplasm. Positive control: Human lung and colon cancer tissue. Recommended dilution: 1/50-150  The image on the left is immunohistochemistry of paraffin-embedded Human lung and colon cancer tissue using HMOX1 antibody at dilution 1/40, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Western blot analysis of HO-1 using a 1:1000 dilution of the antibody Mouse IgG1 1F12-A6 Purified Bov, Hu, Ms C, E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Western blot analysis of HO-1 in a human cell line mix using a 1:1000 dilution of the antibody Rabbit Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Western blot analysis of extracts of various cell lines, using HMOX1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Immunohistochemistry: Heme Oxygenase 1 Antibody [TA336832] - Analysis of heme oxygenase mouse kidney using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Immunohistochemistry: Heme Oxygenase 1 Antibody [TA336833] - Analysis of Heme Oxygenase 1 in mouse kidney using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Western blot analysis of HO-1 expression in fetal liver lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heme oxygenase 1 / HMOX1 antibody

Western blot analysis of HO-1 using a 1:1000 dilution of the antibody Mouse IgG1 1F12-A6 Purified Bov, Hu, Ms C, E, ICC/IF, IP, WB
25 µg / €230.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 antibody

Western blot analysis of HO-1 expression in Jurkat cell lysate using HO-1 antibody Cat.-No AP00140PU-N. Rabbit Aff - Purified Hst, Hu, Ms, Rt IP, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 antibody

Immunohistochemistry: AP21303PU-N HMOX1 Antibody staining of Formalin-Fixed, Spleen at 10 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Can, Hst, Hu, Mky, Ms, Rb, Rt IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 antibody

Formalin-Fixed, Paraffin-Embedded Human Placenta stained with Heme oxygenase 1 / HMOX1 Antibody Cat.-No AP22888PU-N at 10 µg/ml after heat-induced antigen retrieval. Rabbit Purified Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 antibody

Formalin-Fixed, Paraffin-Embedded Human Spleen stained with  Heme oxygenase 1 / HMOX1  Antibody Cat.-No AP22896PU-N at 10 µg/ml after heat-induced antigen retrieval. Rabbit Purified Can, Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 (Center) antibody

Western blot analysis of HMOX1 (arrow) using Heme oxygenase 1 / HMOX1 Antibody (Center) Cat.-No AP52064PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HMOX1 gene. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 antibody

Heme oxygenase 1 / HMOX1 Rabbit IgG Aff - Purified Bov, Hu, Ms, Por, Rt C, WB
50 µg / €620.00
  Acris Antibodies GmbH

Heme oxygenase 1 / HMOX1 antibody

Heme oxygenase 1 / HMOX1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Heme oxygenase 1 / HMOX1 antibody

Heme oxygenase 1 / HMOX1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Heme oxygenase 1 / HMOX1 antibody

Immunofluorescence of purified MaxPab antibody to HMOX1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Heme oxygenase 1 / HMOX1 antibody

HMOX1 MaxPab rabbit polyclonal antibody. Western Blot analysis of HMOX1 expression in human spleen. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Heme oxygenase 1 / HMOX1 antibody

Detection limit for recombinant GST tagged HMOX1 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 5C6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Heme oxygenase 1 / HMOX1 antibody

Heme oxygenase 1 / HMOX1 Mouse IgG1 GTS-1 Hu, Ms, Rt C, E, P, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

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