Heparanase / HPSE antibody

Principal name

Heparanase / HPSE antibody

Alternative names for Heparanase / HPSE antibody

HEP, HPA, HPA1, HPR1, HPSE1, HSE1, Heparanase-1, Endo-Glucoronidase

SwissProt ID

Q6YGZ1 (Mouse), Q71RP1 (Rat), Q90YK5 (Chick), Q9MYY0 (Bovin), Q9Y251 (Human)

Gene ID

10855 (HPSE)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of Heparanase / HPSE antibody

Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasation of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50kD subunit harboring the active site and a 8kD subunit. It is produced as a latent 65kD precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.

General readings

Navarro F.P. et al. Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. J Neurochem. 2008 Apr;105(1):34-45.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Heparanase / HPSE antibody

  Anti-HPSE Rabbit Polyclonal Antibody  
Predicted band size: 61 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 60 ug Primary antibody: 1/100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heparanase / HPSE antibody

  Anti-HPSE Rabbit Polyclonal Antibody  
Predicted band size: 61 kDa . Positive control: Human transitional cell carcinoma tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 60 ug Primary antibody: 1/100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Heparanase / HPSE antibody

  Rabbit anti-HPSE Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using HPSE antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Heparanase / HPSE antibody

  Rabbit Polyclonal Anti-HPSE Antibody  
WB Suggested Anti-HPSE Antibody; Titration: 1.0 ug/ml; Positive Control: Jurkat Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Heparanase / HPSE antibody

  Rabbit Polyclonal Anti-HPSE Antibody  
WB Suggested Anti-HPSE Antibody; Titration: 1.0 ug/ml; Positive Control: Jurkat Whole Cell Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Heparanase / HPSE antibody

Immunohistochemistry: AP08811PU-N Heparanase antibody staining of Formalin-Fixed Paraffin-Embedded of Human Spleen at 5 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Heparanase / HPSE antibody

Heparanase / HPSE Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Heparanase / HPSE antibody

Detection limit for recombinant GST tagged HPSE is approximately 0.3ng/ml as a capture antibody. Mouse IgG2b 4D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Heparanase / HPSE antibody

Western Blot analysis of HPSE expression from cell extracts with HPSE polyclonal antibody ( Cat # PAB12311 ).
Lane 1 : smmc cell lysate.
Lane 2 : HT1080 whole cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Heparanase / HPSE (N-term) antibody

Human Jurkat; WB Suggested Anti-HPSE Antibody. . Titration: 1.0 ug/ml. . Positive Control: Jurkat Whole Cell; HPSE antibody - N-terminal region (ARP60765_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Heparanase / HPSE (N-term) antibody

Human Jurkat; WB Suggested Anti-HPSE Antibody. . Titration: 1.0 ug/ml. . Positive Control: Jurkat Whole Cell; HPSE antibody - N-terminal region (ARP60766_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Heparanase / HPSE antibody

Heparanase / HPSE Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

CRISPR

Catalog No. Species Donor Vector  

HPSE - human gene knockout kit via CRISPR

HPSE - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HPSE - human gene knockout kit via CRISPR

HPSE - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HPSE - human gene knockout kit via CRISPR

HPSE - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HPSE - human gene knockout kit via CRISPR

HPSE - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Heparanase / HPSE (N-term HIS tag, transcript variant 1)

  Purified recombinant protein of Human heparanase (HPSE), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug  
Heparanase / HPSE Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Heparanase / HPSE (36-543, His-tag)

Heparanase / HPSE Human Purified > 85 % pure by SDS-PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Heparanase / HPSE (36-543, His-tag)

Heparanase / HPSE Human Purified > 85 % pure by SDS-PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Heparanase / HPSE

Heparanase / HPSE Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
10 µg / €380.00
  Abnova Taiwan Corp.

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