Hepatitis B X Protein / HBx antibody

Principal name

Hepatitis B X Protein / HBx antibody

Alternative names for Hepatitis B X Protein / HBx antibody

HBV Protein X

Available reactivities

Hu (Human), Vi (Virus)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P)

Background of Hepatitis B X Protein / HBx antibody

The recombinant Hepatitis B Protein X is 100% homologous with the natural Hepatitis B Protein X. Hepatitis B virus X protein (HBx) is a 17 kD transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. It regulates many transcription factors including nuclear factor kappa B (NF-kappaB) and plays a key role in hepatocarcinogenesis. HBx facilitates the binding of cAMP response element binding protein (CREB) to its responsive element. HBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells. HBx transactivates both JNK and MAPK signal transduction pathways in association with the mobilization of cytosolic Ca2+. The communication between HBx and general transcription factor TFIIB is also one of the mechanisms which account for its transcriptional transactivation. HBx decreased the expression of PTEN a known tumor suppressor and a negative regulator of phosphatidylinositol 3'-kinase/AKT and HBx decreased the expression of PTEN in HBx-transfected cells. The etiology of hepatocellular carcinoma (HCC) is involved with hepatitis B virus (HBV) infection and HBx in particular plays a role in the development of HBV-related HCC. The persistence of HBx is important to the pathogenesis of early HCC and HBx expression in the liver during chronic HBV infection may be an important prognostic marker for the development of HCC.

General readings

General / background references:Somogyi CS Development and characterization of polyclonal and monoclonal antibodies against HBXAg. Progress in Clinical Virology :p.209 (1995).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Hepatitis B X Protein / HBx antibody

Hepatitis B X Protein / HBx Rabbit Aff - Purified E, IP, WB
50 µg / €370.00
  Acris Antibodies GmbH

Hepatitis B X Protein / HBx antibody

Hepatitis B X Protein / HBx Mouse IgG2a 3F6-G10 Purified C, E, P, WB
0.25 mg / €440.00
  Acris Antibodies GmbH

Hepatitis B X Protein / HBx antibody

Hepatitis B X Protein / HBx Mouse IgG2a 3F6-G10 Aff - Purified Hu, Vi C, E, P, WB
0.125 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Hepatitis B X Protein / HBx Tag Free

14% SDS-PAGE separation of HBx Cat.No. PA509X:1. Mol.Weight marker - 14, 21, 31, 45, 66, 97 kDa2. reduced and heated sample, 5μg/lane3. non-reduced and non-heated sample, 2.5μg/lane Human Purified > 95 % determined by densitometric image analysis
0.1 mg / €470.00
  Acris Antibodies GmbH

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