Hepatocyte growth factor / HGF antibody

Principal name

Hepatocyte growth factor / HGF antibody

Alternative names for Hepatocyte growth factor / HGF antibody

Scatter factor, Hepatopoeitin-A, HPTA

SwissProt ID

P14210 (Human), P17945 (Rat), Q08048 (Mouse), Q76BS1 (Bovin), Q867B7 (Canfa), Q9BH09 (Felca), Q9BYM0 (Human)

Gene ID

3082 (HGF), 285 (ANGPT2), 1093082 (fadE12), 15234 (Hgf), 24446

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rb (Rabbit), Rt (Rat), Chk (Chicken), Eq (Equine), Por (Porcine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Neutralisation (NEUT)

Background of Hepatocyte growth factor / HGF antibody

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity.Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

General readings

General / background references:Strain AJ Hepatocyte growth factor: another ubiquitous cytokine. J Endocrinol 137:1-5 (1993). PubMed PMID: 8492067
Rubin JS et al. A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A 88:415-9 (1991). PubMed PMID: 1824873
Stoker M et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327:239-42 (1987). PubMed PMID: 2952888
Nakamura T et al. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc Natl Acad Sci U S A 83:6489-93 (1986). PubMed PMID: 3529086

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Hepatocyte growth factor / HGF antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-HGF mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807184)(1:150) Mouse IgG2a OTI1D2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Hepatocyte growth factor / HGF antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-HGF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807186) Mouse IgG1 OTI2F3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Hepatocyte growth factor / HGF antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-HGF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807223) Mouse IgG1 OTI3F2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Hepatocyte growth factor / HGF antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between HGF and MET. Mahlavu cells were stained with anti-HGF rabbit purified polyclonal 1:1200 and anti-MET mouse purified polyclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Hepatocyte growth factor / HGF antibody

Anti-HGF antibody IHC of human brain, cerebellum, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Mouse IgG2a 7-2 Purified Hu, Ms P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

Hepatocyte growth factor / HGF antibody

Western blot analysis of extracts of 293T cell line, using HGF antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Hepatocyte growth factor / HGF antibody

WB Suggested Anti-HGF Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: 293T cell lysate;There is BioGPS gene expression data showing that HGF is expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hepatocyte growth factor / HGF antibody

WB Suggested Anti-HGF Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Eq, GP, Hu, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hepatocyte growth factor / HGF antibody

WB Suggested Anti-HGF Antibody Titration: 0.2-1 ug/ml; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Hepatocyte growth factor / HGF antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HGF (RC215593, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HGF.(1:2000) Mouse IgG2b OTI1C6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Hepatocyte growth factor / HGF antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-HGF mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807224)(1:150) Mouse IgG1 OTI1E5 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Hepatocyte growth factor / HGF (C-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with HGF antibody (C-term) (AP11675PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Hepatocyte growth factor / HGF (521-554) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu E, F, P, WB
0.2 ml / €470.00
  Acris Antibodies GmbH

Hepatocyte growth factor / HGF antibody

Hepatocyte growth factor / HGF Rabbit Purified Hu E, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

Hepatocyte growth factor / HGF antibody

Hepatocyte growth factor / HGF Rabbit Aff - Purified Hu E, WB
50 µg / €280.00
  Acris Antibodies GmbH

Hepatocyte growth factor / HGF antibody

Hepatocyte growth factor / HGF Rabbit Purified Hu E, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

Hepatocyte growth factor / HGF antibody

Hepatocyte growth factor / HGF Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Hepatocyte growth factor / HGF antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with HGF polyclonal antibody ( Cat # PAB3683 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Hepatocyte growth factor / HGF antibody

Human Adrenal Gland; Immunohistochemistry with Human Adrenal Gland lysate tissue at an antibody concentration of 5.0ug/ml using anti-HGF antibody (ARP44317_P050); HGF antibody - N-terminal region (ARP44317_P050) in Human Adrenal Gland cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Hepatocyte growth factor / HGF antibody

Human Placenta; WB Suggested Anti-HGF Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Placenta; HGF antibody - N-terminal region (ARP44318_P050) in Human Placenta cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rb, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

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