Alternative names for HERC2 antibody
Probable E3 ubiquitin-protein ligase HERC2, HECT domain and RCC1-like domain-containing protein 2
Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of HERC2 antibody
HERC2 is a belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.