Herpes Virus Type 8 / HHV8 antibody

Principal name

Herpes Virus Type 8 / HHV8 antibody

Alternative names for Herpes Virus Type 8 / HHV8 antibody

HHV-8, KHSV

Gene ID

4961461

Available reactivities

Hu (Human), Vi (Virus)

Available hosts

Rat, Mouse, Rabbit, Sheep

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP)

Background of Herpes Virus Type 8 / HHV8 antibody

ORF57 (also known as MTA), one of the earliest Kaposi's sarcoma-associated herpesvirus (KSHV) regulatory proteins to be expressed, is essential for virus lytic replication. A counterpart is present in every herpesvirus sequenced, indicating the importance of this signature viral protein, and those examined act post-transcriptionally, affecting RNA splicing and transport. KSHV ORF57 is capable of establishing both lytic and latent replication cycles. In KS, the virus localizes to tumor progenitor endothelial cells, most of which are latently infected. In cell culture, KSHV replication is generally studied using B-cell lines, such as BCBL-1, generated from primary effusion lymphoma material. Most BCBL-1 cells are latently infected, although there is some spontaneous virus reactivation. Addition of chemical inducers such as sodium n-butyrate, 12-O-tetradecanoylphorbol-13-acetate (TPA), and valproic acid (VA) to these cells efficiently induces the lytic cycle and produces virions. KSHV ORF57 protein predominantly localizes to the nucleus and can shuttle between the nucleus and cytoplasm. Most HSV-1 genes are unspliced; by contrast, ORF57 is spliced gene; the protein is 455 amino acids in length and 50kDa in size.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Herpes Virus Type 8 / HHV8 ORF62 antibody

Herpes Virus Type 8 / HHV8 Sheep IgG Purified WB
0.25 mg / €370.00
  Acris Antibodies GmbH

Herpes Virus Type 8 / HHV8 Cyclin antibody

Herpes Virus Type 8 / HHV8 Sheep IgG Purified Hu IP, WB
0.25 mg / €370.00
  Acris Antibodies GmbH

Herpes Virus Type 8 / HHV8 ORF57 antibody

Western blot using affinity purified anti-KSHV FORF57 to detect KSHV ORF57 in HEK293 cells transfected with ORF57 expression vector and ORF57 truncations, or in KSHV infected B-cell line (BCBL-1) treated with or without valproic acid to induce viral replication (arrow). The membrane was probed with the primary antibody diluted 1:7,500 (left) and 1:1,000 (right). Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Herpes Virus Type 8 / HHV8 ORF57 antibody

Western blot using affinity purified anti-KSHV FORF57 to detect KSHV ORF57 in HEK293 cells transfected with ORF57 expression vector and ORF57 truncations, or in KSHV infected B-cell line (BCBL-1) treated with or without valproic acid to induce viral replication (arrow). The membrane was probed with the primary antibody diluted 1:7,500 (left) and 1:1,000 (right). Rabbit IgG Aff - Purified Hu E, WB
25 µl / €190.00
  Acris Antibodies GmbH

Herpes Virus Type 8 / HHV8 antibody

Cultured cells infected with HHV8 stained with HHV8 antibody DM395 /DM395-05 (Clone LN53). Rat IgG2c LN53 Purified Hu P
1 ml / €530.00
  Acris Antibodies GmbH

Herpes Virus Type 8 / HHV8 antibody

Cultured cells infected with HHV8 stained with HHV8 antibody DM395 /DM395-05 (Clone LN53). Rat IgG2c LN53 Purified Hu P
0.5 ml / €350.00
  Acris Antibodies GmbH

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