HES2 antibody

Principal name

HES2 antibody

Alternative names for HES2 antibody

Transcription factor HES-2, BHLHB40, Hairy and enhancer of split 2, Class B basic helix-loop-helix protein 40

SwissProt ID

O54792 (Mouse), P35429 (Rat), Q00P32 (Xenla), Q9Y543 (Human)

Gene ID

54626 (HES2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of HES2 antibody

The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

General readings

Akazawa C., et al. (1992) J Biol Chem. 267:21879-21885.Ishibashi M., et al. (1993) J Biochem. 215:645-652.

19 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HES2 antibody

HES2 Mouse IgG2a 4H6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2a 3H1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2a 2G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2a 1B12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2a 4A5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2b 2F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2a 3C2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2b 1D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2a 3B3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

HES2 Mouse IgG2b 1D5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HES2 antibody

Western blot analysis of HES2 expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

HES2 antibody

Western blot analysis of HES2 expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

HES2 antibody

Western blot analysis of HES2 expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

HES2 antibody

Immunohistochemistry-Paraffin: HES2 Antibody [NBP1-88628] Immunohistochemical staining of human lateral ventricle shows moderate cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HES2

HES2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

HES2 (1-173, His-tag)

HES2 Human Purified > 80 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

HES2 (1-173, His-tag)

HES2 Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

HES2

HES2 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HES2 overexpression lysate

HES2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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