HES6 antibody

Principal name

HES6 antibody

Alternative names for HES6 antibody

Transcription cofactor HES-6, C-HAIRY1, BHLHB41, Hairy and enhancer of split 6, Class B basic helix-loop-helix protein 41

SwissProt ID

Q96HZ4 (Human), Q9JHE6 (Mouse)

Gene ID

55502 (HES6), 55927 (Hes6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP)

Background of HES6 antibody

The Drosophila hairy and enhancer of split genes encode basic helix-loophelix (bHLH) transcriptional repressors that function in the notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of groucho, and this interaction is mediated by the carboxy-terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N-box (CACNAG) as opposed to the E-box (CANNTG). HES2 binds to both N- and E-box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues.

General readings

lubb, D.M., et al. Neurosci. Lett. 460(2):185-190(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Eun, B., et al. J. Biol. Chem. 283(9):5939-5949(2008)
Scheffer, D., et al. FEBS Lett. 581(24):4651-4656(2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HES6 antibody

  Rabbit polyclonal anti-HES6 antibody  
Western blot analysis of extracts from HeLa cells, using HES6 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

HES6 antibody

  Rabbit Polyclonal Anti-Hes6 Antibody  
WB Suggested Anti-Hes6 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Stomach Rabbit IgG Purified Hu, Ms WB
50 µg / €360.00
  OriGene Technologies, Inc.

HES6 antibody

  Rabbit Polyclonal Anti-HES6 Antibody  
WB Suggested Anti-HES6 Antibody Titration: 1.25ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

HES6 antibody

  HES6 mouse monoclonal antibody, clone OTID6 (formerly D6)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES6 (RC203205, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES6. Mouse IgG1 OTID6 Purified Hu WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

HES6 antibody

  HES6 mouse monoclonal antibody, clone OTIH2 (formerly H2)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES6 (RC203205, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES6. Mouse IgG1 OTIH2 Purified Hu WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

HES6 antibody

  HES6 mouse monoclonal antibody, clone OTIH10 (formerly H10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES6 (RC203205, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES6. Mouse IgG2a OTIH10 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

HES6 antibody

  HES6 mouse monoclonal antibody, clone OTIF7 (formerly F7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES6 (RC203205, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES6. Mouse IgG1 OTIF7 Purified Hu WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

HES6 antibody

Immunohistochemistry analysis of HES-6 antibody (Cat.-No AP20454PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HES6 (N-term) antibody

Western blot analysis of HES6 Antibody (N-term) Cat.-No AP52033PU-N in MCF-7 cell line lysates (35ug/lane). HES6 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HES6 antibody

HES6 Rabbit Purified Hu C, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

HES6 antibody

Western blot analysis of extracts from HeLa cells, using HES6 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

HES6 antibody

Western blot analysis of extracts from HeLa cells, using HES6 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HES6 (transcript variant 1)

  Recombinant protein of human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 1  
HES6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

HES6 overexpression lysate

HES6 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

HES6 overexpression lysate

HES6 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HES6 (mGFP-tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, HES6 (mGFP-tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, HES6 (mGFP-tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, HES6 (mGFP-tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, HES6 (Myc-DDK tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, HES6 (Myc-DDK tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Lenti ORF particles, HES6 (Myc-DDK tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, HES6 (Myc-DDK tagged) - Human hairy and enhancer of split 6 (Drosophila) (HES6), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hes6 (GFP-tagged) - Mouse hairy and enhancer of split 6 (Drosophila) (Hes6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hes6 (GFP-tagged) - Mouse hairy and enhancer of split 6 (Drosophila) (Hes6), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

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