HFE / HLAH antibody

Principal name

HFE / HLAH antibody

Alternative names for HFE / HLAH antibody

Hereditary hemochromatosis protein

SwissProt ID

O35799 (Rat), P70387 (Mouse), Q30201 (Human), Q30201-4

Gene ID

3077 (HFE)

Available reactivities

Hu (Human), Bov (Bovine), Rt (Rat), Ms (Mouse), Eq (Equine), Rb (Rabbit), Can (Canine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C)

Background of HFE / HLAH antibody

The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.

General readings

Feder J.N., et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95:1472-1477West, A P, et al. (2000) J. Biol. Chem. (UNITED STATES) 275 (49): 38135–8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HFE / HLAH antibody

Immunofluorescence of monoclonal antibody to HFE on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 1G12 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HFE / HLAH antibody

Western blot analysis of extracts from LOVO cells, using HLAH antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HFE / HLAH antibody

Western blot analysis of extracts of various cell lines, using HFE antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

HFE / HLAH antibody

WB Suggested Anti-HFE Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate;There is BioGPS gene expression data showing that HFE is expressed in HeLa Rabbit IgG Purified Bov, Eq, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HFE / HLAH antibody

WB Suggested Anti-HFE Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

HFE / HLAH (Center) antibody

Western blot analysis of HFE antibody (Center) (AP17460PU-N) in Jurkat cell line lysates (35 µg/lane). HFE (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HFE / HLAH antibody

Western blot (WB) analysis of HLA-H antibody (Cat.-No.: AP21189PU-N) in extracts from LOVO cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HFE / HLAH antibody

HFE / HLAH Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

HFE / HLAH antibody

HFE MaxPab polyclonal antibody. Western Blot analysis of HFE expression in HepG2. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

HFE / HLAH antibody

Western Blot analysis of HFE expression in transfected 293T cell line (H00003077-T01) by HFE MaxPab polyclonal antibody.

Lane 1: HFE transfected lysate(40.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HFE / HLAH (N-term) antibody

Human HeLa; WB Suggested Anti-HFE Antibody Titration: 0.2-1 ug/ml. Positive Control: Hela cell lysate. There is BioGPS gene expression data showing that HFE is expressed in HeLa.; HFE antibody - N-terminal region (ARP44283_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

HFE / HLAH antibody

Human kidney; HFE antibody - C-terminal region (ARP44285_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Hu, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

HFE / HLAH antibody

HFE / HLAH Rabbit Aff - Purified Hu WB
0.1 mg / €420.00
  Novus Biologicals Inc.

HFE / HLAH antibody

Western Blot: HFE Antibody [NBP1-59054] - This Anti-HFE antibody was used in Western Blot of Hela       tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

HFE / HLAH antibody

Western Blot: HFE Antibody [NBP1-59055] - This Anti-HFE antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 0.25ug/ml. Rabbit Aff - Purified Hu P, WB
50 µg / €440.00
  Novus Biologicals Inc.

HFE / HLAH antibody

Immunohistochemistry-Paraffin: HFE Antibody [NBP1-83250] Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HFE / HLAH

HFE / HLAH Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

HFE / HLAH

HFE / HLAH Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

HFE / HLAH

HFE / HLAH Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

HFE / HLAH (23-306, His-tag)

HFE / HLAH Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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