HFE2 / Hemojuvelin antibody

Principal name

HFE2 / Hemojuvelin antibody

Alternative names for HFE2 / Hemojuvelin antibody

HJV, RGMC, Hemochromatosis type 2 protein, RGM domain family member C

SwissProt ID

Q6ZVN8 (Human), Q7TQ32 (Mouse), Q8N7M5 (Rat)

Gene ID

148738 (HFE2), 69585 (Hfe2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of HFE2 / Hemojuvelin antibody

Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of a three gene family (in vertebrates) called the repulsive guidance molecules. In mouse, the Hemojuvelin protein is encoded by the HFE2 gene, and it is mapped to Chromosome 3. It was concluded that downregulation of hepatic Hemojuvelin during inflammation may induce a temporary elimination of iron sensing. Hemojuvelin is a coreceptor for bone morphogenetic proteins (BMPs), and inhibition of endogenous BMP signaling reduces hepcidin expression and increases serum iron in mice. Furthermore, Hemojuvelin may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion.

General readings

Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)
Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)
Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HFE2 / Hemojuvelin antibody

Anti-HFE2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Mouse IgG2a 1C12 Purified Hu E, WB
50 µg / €345.00
  OriGene Technologies, Inc.

HFE2 / Hemojuvelin antibody

Western blot analysis of extracts of various cell lines, using HFE2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

HFE2 / Hemojuvelin antibody

WB Suggested Anti-HFE2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HFE2 / Hemojuvelin (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded skeletal muscle reacted with HFE2 / Hemojuvelin Antibody (Center) Cat.-No AP52036PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HFE2 / Hemojuvelin (C-term) antibody

Western blot analysis of HFE2 / Hemojuvelin Antibody (C-term) Cat.-No AP52037PU-N in HepG2 cell line lysates (35ug/lane). HFE2 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HFE2 / Hemojuvelin antibody

HFE2 polyclonal antibody (A01), Lot # 060519JCS1 Western Blot analysis of HFE2 expression in U-2 OS ( Cat # L022V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

HFE2 / Hemojuvelin antibody

Western Blot analysis of HFE2 expression in transfected 293T cell line (H00148738-T01) by HFE2 MaxPab polyclonal antibody.

Lane 1: HFE2 transfected lysate(34.43 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

HFE2 / Hemojuvelin antibody

HFE2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HFE2 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HFE2 / Hemojuvelin antibody

Immunoperoxidase of monoclonal antibody to HFE2 on formalin-fixed paraffin-embedded human liver. [antibody concentration 3 ug/ml] Mouse IgG2a 1C12 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HFE2 / Hemojuvelin antibody

HFE2 / Hemojuvelin Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HFE2 / Hemojuvelin

HFE2 / Hemojuvelin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

HFE2 / Hemojuvelin

HFE2 / Hemojuvelin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HFE2 293T Cell Transient Overexpression Lysate(Denatured)

HFE2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HFE2 overexpression lysate

HFE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

HFE2 overexpression lysate

HFE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HFE2 (mGFP-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant a, 200 uL, >10^7 TU/mL

Lenti ORF particles, HFE2 (mGFP-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant a, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, HFE2 (mGFP-tagged) - Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b, 200 uL, >10^7 TU/mL

Lenti ORF particles, HFE2 (mGFP-tagged) - Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, HFE2 (mGFP-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant c, 200 uL, >10^7 TU/mL

Lenti ORF particles, HFE2 (mGFP-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant c, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, HFE2 (mGFP-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant d, 200 uL, >10^7 TU/mL

Lenti ORF particles, HFE2 (mGFP-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant d, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, HFE2 (Myc-DDK-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant a, 200 uL, >10^7 TU/mL

Lenti ORF particles, HFE2 (Myc-DDK-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant a, 200 uL, >10^7 TU/mL  
200 µl / €910.00
  OriGene Technologies, Inc.

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