HGF receptor antibody

Principal name

HGF receptor antibody

Alternative names for HGF receptor antibody

Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met, Met proto-oncogene tyrosine kinase

SwissProt ID

P08581 (Human), P16056 (Mouse), P97523 (Rat), Q2QLE0 (Pig), Q769I5 (Bovin)

Gene ID

4233 (MET), 24553 (Met)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Rb (Rabbit), Bov (Bovine), Por (Porcine)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP)

Background of HGF receptor antibody

c-Met, a member of the tyrosine kinase superfamily, is the receptor for hepatocyte growth factor, also known as scatter factor (HGF/SF). The mature c-Met protein is a disulfide-linked heterodimer with Mr=190 kDa composed of a heavily glycosylated alpha subunit that is completely extracellular in localization, and a beta subunit comprising an extracellular ligand binding domain, a single transmembrane domain, and a cytoplasmic tyrosine kinase domain. Cells expressing c-Met include epithelial cells, endothelial cells, blood cells of various types, and glomerular mesenchymal cells.

HGF/SF binding to c-Met stimulates receptor dimerization and the phosphorylation of numerous residues within the receptor’s cytoplasmic domain. Signaling proteins that are phosphorylated and/or localized in response to c-Met phosphorylation include: Grb2, Shc, Cbl, Crk, cortactin, paxillin, GAB1, PI3K, FAK, Src, Ras, ERK1 and 2, JNK, PLC gamma, AKT, and STAT3. HGF/SF stimulation of c-Met expressing cells enhances proliferation, migration, morphogenesis, and protease synthesis, characteristics that are associated with invasive cell phenotype. Many types of cancer exhibit sustained c-Met stimulation, overexpression, or mutation, including carcinomas of the colon, breast, ovary, lung, liver, prostate, thyroid, kidney, as well as melanomas and sarcomas. In addition to cancer studies, other research areas in which c-Met is under investigation include organogenesis, organ regeneration, angiogenesis and surgical wound healing.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HGF receptor antibody

  MET mouse monoclonal antibody,clone UMAB190  
Immunohistochemical staining of paraffin-embedded MET positive Human lung carcinoma tissue using anti-MET mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800082)(1:150) Mouse IgG1 UMAB190 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

HGF receptor antibody

  MET mouse monoclonal antibody,clone UMAB190  
Immunohistochemical staining of paraffin-embedded MET positive Human lung carcinoma tissue using anti-MET mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800082)(1:150) Mouse IgG1 UMAB190 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

HGF receptor (catalytic domain) antibody

  Mouse monoclonal MET/HGFR Antibody  
Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent Abgent Ã?s different anti-Met monoclonal antibodies that are Cat# AM1001-1005. Lane 6 represents auto-phosohorylated-Met in HepG2 cell line detected by anti-phospho-Met Mab (Cat# AM1000). Mouse IgG1 4AT44 Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor pTyr1349/1356 antibody

  Rabbit polyclonal c-Met phospho Y1349 / Y1356 antibody  
Western blot using affinity purified anti-c-Met pY1349pY1356 antibody shows detection of phosphorylated c-Met. Human mammary B5/589 epithelial cells were serum-deprived and treated with or without HGF. Cell lysates were immunoprecipated with the anti-c-Met antibody, resolved by SDS-PAGE, transferred to PVDF membrane, and probed with anti-c-Met pY1349pY1356. Personal communication, D. Bottaro and T. Ito, NCI, Bethesda, MD Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

HGF receptor (catalytic domain) antibody

  Mouse monoclonal MET/HGFR Antibody  
Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent Abgent Ã?s different anti-Met monoclonal antibodies that are Cat# AM1001-1005. Lane 6 represents auto-phosohorylated-Met in HepG2 cell line detected by anti-phospho-Met Mab (Cat# AM1000). Mouse IgG1 6AT203 Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor (catalytic domain) antibody

  Mouse monoclonal MET/HGFR Antibody  
Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent Abgent 聮s different anti-Met monoclonal antibodies that are Cat# AM1001-1005. Lane 6 represents auto-phosohorylated-Met in HepG2 cell line detected by anti-phospho-Met Mab (Cat# AM1000). Mouse IgG1 6AT1785 Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor (catalytic domain) antibody

  Mouse monoclonal MET/HGFR Antibody  
Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent Abgent Ã?s different anti-Met monoclonal antibodies that are Cat# AM1001-1005. Lane 6 represents auto-phosohorylated-Met in HepG2 cell line detected by anti-phospho-Met Mab (Cat# AM1000). Mouse IgG1 4AT259 Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor (catalytic domain) antibody

  Mouse monoclonal MET/HGFR Antibody  
Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent Abgent Ã?s different anti-Met monoclonal antibodies that are Cat# AM1001-1005. Lane 6 represents auto-phosohorylated-Met in HepG2 cell line detected by anti-phospho-Met Mab (Cat# AM1000). Mouse IgG1 4AT247 Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Rabbit Polyclonal c-Met Antibody  
HGF receptor Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Rabbit Polyclonal Met Antibody  
Western blot analysis of Met expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Rabbit Polyclonal Met Antibody  
Western blot analysis of Met expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Rabbit Polyclonal Anti-MET Antibody  
HGF receptor Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Mouse monoclonal Anti-c-Met Clone 12.1  
Western blotting using HRP-conjugated mAb 12.1. SNU5 cell lysate was used for immunoprecipitation. SC-10 (rabbit polyclonal) is a control. Mouse IgG1 12.1 Purified Hu ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Rabbit Polyclonal anti-c-Met Antibody  
Human Ovarian Carcinoma stained with anti-c-Met antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  Rabbit Monoclonal anti-c-Met (Paired 1003) Antibody  
Human Breast Carcinoma stained with anti-c-Met (Paired 1003) antibody. Rabbit IgG SP59 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGF receptor antibody

  MET mouse monoclonal antibody, clone OTI2B5 (formerly 2B5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MET (RC217003, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MET. Mouse IgG2b OTI2B5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HGF receptor antibody

  MET mouse monoclonal antibody, clone OTI2H2 (formerly 2H2)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MET (RC217003, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MET. Mouse IgG1 OTI2H2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HGF receptor antibody

  MET mouse monoclonal antibody, clone OTI18A5 (formerly 18A5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MET (RC217003, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MET. Mouse IgG2a OTI18A5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HGF receptor antibody

  MET mouse monoclonal antibody, clone OTI1E6 (formerly 1E6)  
Immunohistochemical staining of paraffin-embedded MET positive Human lung carcinoma tissue using anti-MET mouse monoclonal antibody. (TA805795; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2b OTI1E6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HGF receptor antibody

  MET mouse monoclonal antibody, clone OTI3G5 (formerly 3G5)  
Immunohistochemical staining of paraffin-embedded MET positive Human lung carcinoma tissue using anti-MET mouse monoclonal antibody. (TA805796)  Dilution: 1:150 Mouse IgG1 OTI3G5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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