HGS / HRS antibody

Principal name

HGS / HRS antibody

Alternative names for HGS / HRS antibody

Protein pp110, Hepatocyte growth factor-regulated tyrosine kinase substrate

SwissProt ID

O14964 (Human), Q0V8S0 (Bovin), Q99LI8 (Mouse), Q9JJ50 (Rat)

Gene ID

9146 (HGS)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of HGS / HRS antibody

The hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a zinc-finger protein that interacts with STAM and undergoes tyrosine phosphorylation in response to IL2, CSF2 or HGF. Hrs is involved in intracellular trafficking and signal transduction and is associated with early endosomes. H contains a phosphatidylinositol 3-phosphate-binding domain that contributes to its endosomal targeting, where Hrs colocalizes with Clathrin via a Clathrin box motif at the carboxy terminus of Hrs. Hrs is essential for ventral folding morphogenesis and shares structual similarity to the yeast protein Vps27p, which is involved in vacuolar protein sorting. The human Hrs gene, which maps to chromosome 17q25, enodes a 777 amino acid protein. In Schwann cells, Hrs colocalizes at endosomes with the tumor suppressor protein schwannomin, suggesting a role for schwannomin in Hrs-mediated cell signaling.

General readings

Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N, Sugamura K. Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. J Biol Chem. 2005 Mar 18;280(11):10468-77. Epub 2005 Jan 7. PMID: 15640163

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HGS / HRS antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

HGS / HRS antibody

Immunofluorescence of monoclonal antibody to HGS on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 6D11 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HGS / HRS antibody

TA303100 (2.5µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HGS / HRS antibody

Western blot analysis of extracts from 293 cells and JK cells, using HGS antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGS / HRS antibody

Western blot analysis of extracts from HUVEC cells, COLO cells and 293 cells, using HRS (Ab-334) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HGS / HRS antibody

Western blot analysis on HepG2 cell lysate using HGS Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HGS / HRS antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HGS (RC200609, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HGS. Mouse IgG2b OTI1C2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HGS / HRS antibody

Anti-HGS mouse monoclonal antibody (TA505894) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HGS(RC200609). Mouse IgG2b OTI3H7 Purified Hu ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

HGS / HRS (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HGS / HRS antibody

Immunohistochemistry analyzes of HRS antibody Cat.-No AP20247PU-N in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HGS / HRS antibody

Immunohistochemistry analyzes of Hrs antibody (Cat.-No.: AP20509PU-N) in paraffin-embedded Human testis tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HGS / HRS antibody

HGS polyclonal antibody (A01), Lot # 051115JC01 Western Blot analysis of HGS expression in Jurkat ( Cat # L017V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

HGS / HRS antibody

Western Blot analysis of HGS expression in transfected 293T cell line (H00009146-T01) by HGS MaxPab polyclonal antibody.

Lane 1: HGS transfected lysate(86.20 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

HGS / HRS antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with HGS polyclonal antibody ( Cat # PAB4227 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma . Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

HGS / HRS antibody

HGS polyclonal antibody ( Cat # PAB7009 ) ( 2.5 µg/ml ) staining of paraffin embedded human testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu E, P
0.1 mg / €400.00
  Abnova Taiwan Corp.

HGS / HRS pTyr334 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using HRS (Phospho-Tyr334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

HGS / HRS pTyr334 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using HRS (Phospho-Tyr334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

HGS / HRS antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HRS (Ab-334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

HGS / HRS antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HRS (Ab-334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

HGS / HRS antibody

Immunohistochemistry analysis of paraffin-embedded human testis tissue, using HGS Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

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