HIC1 / ZBTB29 antibody

Principal name

HIC1 / ZBTB29 antibody

Alternative names for HIC1 / ZBTB29 antibody

HIC-1, Hypermethylated in cancer 1 protein, Zinc finger and BTB domain-containing protein 29

SwissProt ID

Q14526 (Human), Q14526-2, Q90850 (Chick), Q9R1Y5 (Mouse)

Gene ID

3090 (HIC1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), GP (Guinea Pig), Eq (Equine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of HIC1 / ZBTB29 antibody

Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

General readings

Chopin,V. (2006) Med Sci (Paris) 22 (1), 54-61

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HIC1 / ZBTB29 antibody

Immunofluorescence of monoclonal antibody to HIC1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2b 4E11 Purified Hu, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

Immunofluorescence of monoclonal antibody to HIC1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2b 2F9 Purified Hu, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 (193-204) antibody

HEK293 overexpressing Human HIC1 and probed with HIC1 Antibody Cat.-No AP32956PU-N (Left) and Cat.-No AP32955PU-N (Right) at 0.5 ?g/ml with the mock transfection in second lane. Data obtained from Dr. D. Leprince, CNRS UMR 8161, Institut de Biologie de LILLE, France. Goat Aff - Purified Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

HIC1 / ZBTB29 (396-410) antibody

HEK293 overexpressing Human HIC1 and probed with HIC1 Antibody Cat.-No AP32956PU-N (Left) and Cat.-No AP32955PU-N (Right) at 0.5 µg/ml with the mock transfection in second lane. Data obtained from Dr. D. Leprince, CNRS UMR 8161, Institut de Biologie de LILLE, France. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

HIC1 / ZBTB29 antibody

WB Suggested Anti-HIC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: COLO205 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

HIC1 / ZBTB29 antibody

WB Suggested Anti-HIC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HIC1 / ZBTB29 antibody

WB Suggested Anti-HIC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: 721_B cell lysate.HIC1 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HIC1 / ZBTB29 antibody

HIC1 / ZBTB29 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

Detection limit for recombinant GST tagged HIC1 is approximately 3ng/ml as a capture antibody. Mouse IgG2a 1E11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

HIC1 / ZBTB29 Mouse IgG2a 2C1 Purified Hu E
50 µg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

HIC1 / ZBTB29 Mouse IgG2a 2C1 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

HIC1 / ZBTB29 Mouse IgG2a 1F2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

HIC1 / ZBTB29 Mouse IgG2a 3B2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

HIC1 / ZBTB29 Mouse IgG2a 2B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HIC1 / ZBTB29 antibody

Human COLO205; WB Suggested Anti-HIC1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: COLO205 cell lysate; HIC1 antibody - N-terminal region (ARP31936_P050) in Human COLO205 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

HIC1 / ZBTB29 antibody

Human Jurkat; WB Suggested Anti-HIC1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Jurkat cell lysate; HIC1 antibody - N-terminal region (ARP32623_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

HIC1 / ZBTB29 antibody

Human 721_B; WB Suggested Anti-HIC1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: 721_B cell lysate. HIC1 is supported by BioGPS gene expression data to be expressed in 721_B.; HIC1 antibody - middle region (ARP38806_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

HIC1 / ZBTB29 antibody

Immunohistochemistry-Paraffin: HIC1 Antibody [NBP1-80607] Immunohistochemical staining of human lung shows strong cytoplasmic positivity in macrophages. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HIC1 / ZBTB29 (transcript variant 1)

HIC1 / ZBTB29 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

HIC1 / ZBTB29

HIC1 / ZBTB29 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

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