HIP1-interacting protein antibody

Principal name

HIP1-interacting protein antibody

Alternative names for HIP1-interacting protein antibody

IFT57, DERP8, ESRRBL1, HIPPI, MHS4R2, Intraflagellar transport protein 57 homolog, Estrogen-related receptor beta-like protein 1, Dermal papilla-derived protein 8

SwissProt ID

Q5EA95 (Bovin), Q8BXG3 (Mouse), Q9NWB7 (Human)

Gene ID

55081 (IFT57), 73916 (Ift57)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of HIP1-interacting protein antibody

HIPPI was identified as a protein that interacts with HIP1 (Huntingtin-interacting protein 1). HIPPI mRNA is expressed in the brain. It is present in all regions of the brain, and to a lesser extent in spinal cord. It is also expressed abundantly in heart, kidney, and lung, with weaker expression in all other tissues tested. HIPPI is expressed in the Golgi apparatus of neurons where it partly colocalizes with HIP1. HIPPI forms a heterodimer with HIP1. The availability of free HIP1 is modulated by polyglutamine length within huntingtin, with disease-associated polyglutamine expansion favoring the formation of proapoptotic HIPPI-HIP1 heterodimers. These heterodimers can recruit procaspase-8 into a complex of HIPPI, HIP1, and procaspase-8 and launch apoptosis through components of the extrinsic cell death pathway. This novel non-receptor-mediated pathway for activating caspase-8 might contribute to neuronal death in Huntington disease.

General readings

Niu Q, Ybe JA.
Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).
J. Mol. Biol. 2008 Feb 375 (5): 1197-205.
PMID: 18155047

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HIP1-interacting protein antibody

  anti-IFT57 (HIPPI) mouse monoclonal antibody, clone OTI2G3 (formerly 2G3)  
Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-IFT57 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500917, Dilution 1:50) Mouse IgG1 OTI2G3 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

HIP1-interacting protein antibody

  anti-IFT57 (HIPPI) mouse monoclonal antibody, clone OTI4F6 (formerly 4F6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-IFT57mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500918, Dilution 1:50) Mouse IgG1 OTI4F6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HIP1-interacting protein antibody

  Mouse Monoclonal Antibody against HIP1 Receptor (1E1)  
Western Blot analysis of HIP1 protein in HeLa cell and rat brain lysates, Mouse IgG1 1E1 Purified Hu, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HIP1-interacting protein antibody

  Goat Anti-HIPPI Antibody  
TA305681 (1ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

HIP1-interacting protein antibody

  anti-IFT57 (HIPPI) mouse monoclonal antibody, clone OTI5B6 (formerly 5B6)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-IFT57 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500906, Dilution 1:50) Mouse IgG1 OTI5B6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

HIP1-interacting protein antibody

  anti-IFT57 (HIPPI) mouse monoclonal antibody, clone OTI1H2 (formerly 1H2)  
Anti-IFT57 mouse monoclonal antibody (TA500907) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IFT57(RC204116). Mouse IgG1 OTI1H2 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CRISPR

Catalog No. Species Donor Vector  

IFT57 - human gene knockout kit via CRISPR

IFT57 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

IFT57 - human gene knockout kit via CRISPR

IFT57 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

IFT57 - human gene knockout kit via CRISPR

IFT57 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IFT57 - human gene knockout kit via CRISPR

IFT57 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ift57 - mouse gene knockout kit via CRISPR

Ift57 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ift57 - mouse gene knockout kit via CRISPR

Ift57 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ift57 - mouse gene knockout kit via CRISPR

Ift57 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ift57 - mouse gene knockout kit via CRISPR

Ift57 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HIP1-interacting protein

  Recombinant protein of human intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)  
HIP1-interacting protein Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ift57 (GFP-tagged) - Mouse intraflagellar transport 57 homolog (Chlamydomonas) (Ift57), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ift57 (GFP-tagged) - Mouse intraflagellar transport 57 homolog (Chlamydomonas) (Ift57), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ift57 (Myc-DDK-tagged) - Mouse intraflagellar transport 57 homolog (Chlamydomonas) (Ift57), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ift57 (Myc-DDK-tagged) - Mouse intraflagellar transport 57 homolog (Chlamydomonas) (Ift57), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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