HIP12 / HIP1R antibody

Principal name

HIP12 / HIP1R antibody

Alternative names for HIP12 / HIP1R antibody

KIAA0655, Huntingtin-interacting protein 12, HIP1-related protein, Huntingtin-interacting protein 1-related protein

SwissProt ID

O75146 (Human), Q9JKY5 (Mouse)

Gene ID

9026 (HIP1R), 100294412 (LOC100294412)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of HIP12 / HIP1R antibody

Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.

General readings

Rose, J. Phd, et al. Mol. Med. (2010) In press
Kim, J.H., et al. Cell. Physiol. Biochem. 23 (1-3), 43-52 (2009)
Wilbur, J.D., et al. J. Biol. Chem. 283(47):32870-32879(2008)
Poupon, V., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):168-173(2008)
Parker, J.A., et al. J. Neurosci. 27(41):11056-11064(2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HIP12 / HIP1R antibody

Immunofluorescence of purified MaxPab antibody to HIP1R on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu, Ms, Rt E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

HIP12 / HIP1R antibody

Immunofluorescence of purified MaxPab antibody to HIP1R on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu, Ms, Rt E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

HIP12 / HIP1R (N-term) antibody

Western blot analysis of HIP12 / HIP1R Antibody (N-term) Cat.-No AP52048PU-N in Ramos cell line lysates (35ug/lane). This demonstrates the HIP1R antibody detected the HIP1R protein (arrow). Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HIP12 / HIP1R antibody

HIP1R MaxPab rabbit polyclonal antibody. Western Blot analysis of HIP1R expression in mouse lung. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HIP12 / HIP1R antibody

HIP1R monoclonal antibody (M01), clone 3E10 Western Blot analysis of HIP1R expression in A-431 ( Cat # L015V1 ). Mouse IgG1 3E10 Purified Hu E, WB
50 µg / €370.00
  Abnova Taiwan Corp.

HIP12 / HIP1R antibody

HIP1R monoclonal antibody (M01), clone 3E10. Western Blot analysis of HIP1R expression in human liver. Mouse IgG1 3E10 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HIP12 / HIP1R

HIP12 / HIP1R Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

HIP12 / HIP1R

HIP12 / HIP1R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

HIP12 / HIP1R

HIP12 / HIP1R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

HIP12 / HIP1R

HIP12 / HIP1R Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

HIP12 / HIP1R

HIP12 / HIP1R Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HIP1R 293T Cell Transient Overexpression Lysate(Denatured)

HIP1R 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HIP1R overexpression lysate

HIP1R overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

13 Item(s)

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