HIRA / TUPLE1 antibody

Principal name

HIRA / TUPLE1 antibody

Alternative names for HIRA / TUPLE1 antibody

DGCR1, HIR, TUP1-like enhancer of split protein 1, HIR histone cell cycle regulation defective homolog A

SwissProt ID

P54198 (Human), P79987 (Chick), Q61666 (Mouse), Q8QFR2 (Xenla)

Gene ID

7290 (HIRA), 15260 (Hira)

Available reactivities

S. cerevisiae (Saccharomyces cerevisiae), Hu (Human), Ms (Mouse), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of HIRA / TUPLE1 antibody

Hira (UniProtKB/Swiss-Prot entry P54198) is a histone chaperone that cooperates with ASF1A to promote replication-independent chromatin assembly. It is important for histone regulation and is required for the periodic repression of histone gene transcription during the cell cycle. Hira plays an important role in the formation of transcriptiolly silent senescence-associated heterochromatic foci (SAHF). SAHF, which contain heterochromatin proteins such as HP1, are believed to repress expression of proliferation-promoting genes, leading to the irreversible cell cycle changes that occur in senescent cells. Interaction between HIRA and ASF1A is the rate limiting step in the formation of SAHF. Hira is also thought to be involved in certain haploinsufficiency syndromes such as DiGeorge syndrome. Insufficient production of Hira protein may disrupt normal embryonic development.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HIRA / TUPLE1 antibody

  Rabbit polyclonal HIRA Antibody (Center)  
HIRA Antibody (Center) (Cat. #TA324826) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HIRA antibody detected the HIRA protein (arrow). Rabbit Ig Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies, Inc.

HIRA / TUPLE1 antibody

  Rabbit Polyclonal Anti-Hira Antibody  
WB Suggested Anti-Hira Antibody Titration: 0.2-1 ug/ml; Positive Control: Mouse Brain Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 ml / €360.00
  OriGene Technologies, Inc.

HIRA / TUPLE1 antibody

Figure 1. Western blot analysis using TUP1 antibody (AM05331PU-N) on recombinant TUP1 protein (amino acids 1-200) expressed in Mav108 cells. Mouse IgG 10 Purified S. cerevisiae WB
0.1 mg / €400.00
  OriGene Technologies GmbH

3 Item(s)

per page
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