Histamine H2 receptor antibody

Principal name

Histamine H2 receptor antibody

Alternative names for Histamine H2 receptor antibody

H2R, HRH2, Gastric receptor I

SwissProt ID

P17124 (Canfa), P25021 (Human), P25102 (Rat), P47747 (Cavpo), P97292 (Mouse)

Gene ID

3274 (HRH2), 25461 (Hrh2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Bt (Bat), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Bear

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Histamine H2 receptor antibody

Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion. The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. H2 receptors couple to adenylate cyclase via Gs, leading to the formation of cAMP and the activation of protein kise A (PKA). H2 receptors are expressed in several tissues including brain, gastrointestil tract and heart. The most studied physiological role of the H2 receptors is their involvement in the regulation of gastric acid secretion. Specific H2 receptor antagonists are currently used for the treatment of acid-related gastrointestil conditions such as peptic ulcer, gastroesophageal reflux disease and dyspepsia. Involvement of H2 receptors in chronic heart failure and immune regulation has also been suggested.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Szukiewicz, D., et al. Inflamm. Res. 59 SUPPL 2, S205-S207 (2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Histamine H2 receptor (C-term) antibody

Histamine H2 receptor Goat Aff - Purified Can, Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

Histamine H2 receptor antibody

  Rabbit Polyclonal antibody to Histamine H2 Receptor (histamine receptor H2)  
Histamine H2 Receptor antibody [N1], N-term detects HRH2 protein by Western blot analysis. A. 30 ug U87-MG whole cell lysate/extract. B. 30 ug SK-N-SH whole cell lysate/extract. 10 % SDS-PAGE. Histamine H2 Receptor antibody [N1], N-term (TA308415) dilutio Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H2 receptor antibody

  Goat Anti-Histamine Receptor H2 (aa309-323) Antibody  
(0.1ug/ml) staining of Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Histamine H2 receptor antibody

  Rabbit polyclonal anti-HRH2 antibody  
Immunofluorescence analysis of LOVO cells, using HRH2 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H2 receptor antibody

  Rabbit Polyclonal Anti-Rat H2 Histamine Receptor (extracellular)  
Western blot analysis of rat basophilic leukemia cells (RBL) (lanes 1 and 3) and rat brain lysates (lanes 2 and 4): 1, 2. Anti-Rat H2 Histamine Receptor (extracellular) antibody , (1:200). 3, 4. Anti- Rat H2 Histamine Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Histamine H2 receptor antibody

  Rabbit Polyclonal Anti-HRH2 Antibody  
WB Suggested Anti-HRH2 Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Brain Rabbit IgG Purified Can, Eq, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Histamine H2 receptor (3rd Cytopl. Dom.) antibody

  Rabbit Polyclonal Anti-HRH2 Antibody (Cytoplasmic Domain)  
Anti-HRH2 / Histamine H2 Receptor antibody IHC of human stomach, parietal cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bt, Can, Elephant, GP, Hst, Hu, Mky, Ms, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Histamine H2 receptor (3rd Extracell. Dom.) antibody

  Rabbit Polyclonal Anti-HRH2 Antibody (Extracellular Domain)  
Anti-HRH2 / Histamine H2 Receptor antibody IHC of human stomach, parietal cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bt, Can, Elephant, GP, Hst, Hu, Mky, Ms, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Histamine H2 receptor antibody

  Rabbit Polyclonal Anti-HRH2 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human fetal muscle tissue, Primary antibody: (HRH2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H2 receptor (Center) antibody

Western blot analysis of HRH2 Antibody (Center) Cat.-No AP52099PU-N in Uterus cell line lysates (35ug/lane). This demonstrates the HRH2 antibody detected the HRH2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Histamine H2 receptor antibody

Immunofluorescence analysis of LOVO cells, using HRH2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €230.00
  Assay Biotech

Histamine H2 receptor antibody

Immunofluorescence analysis of LOVO cells, using HRH2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

HRH2 - human gene knockout kit via CRISPR

HRH2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HRH2 - human gene knockout kit via CRISPR

HRH2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HRH2 - human gene knockout kit via CRISPR

HRH2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HRH2 - human gene knockout kit via CRISPR

HRH2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

HRH2 overexpression lysate

HRH2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HRH2 (mGFP-tagged) - Human histamine receptor H2 (HRH2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, HRH2 (mGFP-tagged) - Human histamine receptor H2 (HRH2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.

Lenti ORF particles, HRH2 (Myc-DDK tagged) - Human histamine receptor H2 (HRH2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, HRH2 (Myc-DDK tagged) - Human histamine receptor H2 (HRH2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hrh2 (GFP-tagged ORF) - Rat histamine receptor H 2 (Hrh2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hrh2 (GFP-tagged ORF) - Rat histamine receptor H 2 (Hrh2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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