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Histamine H4 receptor antibody

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Principal name

Histamine H4 receptor antibody

Alternative names for Histamine H4 receptor antibody

HH4R, GPCR105, HRH4, G-protein coupled receptor 105, GPRv53, SP9144, AXOR35, Pfi-013

SwissProt ID

Q91ZY1 (Rat), Q91ZY2 (Mouse), Q9H3N8 (Human)

Gene ID

59340 (HRH4), 225192 (Hrh4), 170704

Ncbi ID

NP_001137300.1, 9606, NM_021624, NP_694727.1, NM_153087, NM_131909, NM_001160166

Available reactivities

Hu (Human), Mky (Monkey), Prim (Primate), Bov (Bovine), Can (Canine), Eq (Equine), Ms (Mouse), Op (Opossum), Rb (Rabbit), Rt (Rat), Bear

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of Histamine H4 receptor antibody

Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion. The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. H4 Histamine Receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kise (MAPK) cascade. H4 Histamine Receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 Histamine Receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 Histamine Receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production. These studies indicate that H4 Histamine Receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.

SP4670P - Histamine H4 receptor
Immunohistochemical staining of Formalin-fixed, Paraffin-embedded human liver tissue using anti-HRH4 antibody cat. no. SP4670P
SP4670P - Histamine H4 receptor
Cells expressing vector only - immunostained with target antibody
SP4670P - Histamine H4 receptor
Cells expressing target protein - immunostained with target antibody
G372-1 - Histamine H4 receptor
Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide.
TA308703 - Histamine H4 receptor
Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis. A. 30 ug Jurkat whole cell lysate/extract. B. 30 ug Raji whole cell lysate/extract. C. 30 ug NCI-H929 whole cell lysate/extract. 10 % SDS-PAGE. Histamine H4 Rec
TA308703 - Histamine H4 receptor
Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis. A. 30 ug HeLa whole cell lysate/extract. B. 30 ug whole cell lysate/extract of HRH4 shRNA-transfected HeLa cells. 10 % SDS-PAGE. Histamine H4 Receptor antibody
TA315695 - Histamine H4 receptor
Immunofluorescence analysis of LOVO cells, using HRH4 antibody.The picture on the right is treated with the synthesized peptide.
TA315696 - Histamine H4 receptor
Western blot analysis of extracts from K562 cells, using KR2_VZVD Antibody.The lane on the right is treated with the synthesized peptide.
TA328667 - Histamine H4 receptor
Western blot analysis of human chronic myelogenous leukemia (K562) (lanes 1 and 3) and human promyelocytic leukemia (HL-60) (lanes 2 and 4) cell lysates: 1, 2. Anti-Human H4 Histamine Receptor (extracellular) antibody, (1:400). 3, 4. Anti-Human H4 Histamine Receptor (extracellular) antibody, preincubated with the control peptide antigen.
TA328667 - Histamine H4 receptor
Indirect flow cytometry analysis of H4 Histamine Receptor expression in live intact Jurkat (acute T-cell leukemia) cell lines. black line, Unstained cells + goat-anti-rabbit-PE. green line, Cells+ Anti-Human H4 Histamine Receptor (extracellular) antibody, (1:20) + goat-anti-rabbit-PE.
TA340671 - Histamine H4 receptor
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Ovary, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA340671 - Histamine H4 receptor
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA340840 - Histamine H4 receptor
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA340989 - Histamine H4 receptor
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA340989 - Histamine H4 receptor
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Histamine H4 receptor (1st Cytopl. Dom.) antibody
  Rabbit Polyclonal Anti-HRH4 Antibody (Cytoplasmic Domain)  
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Ovary, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Eq, Hu, Mky, Ms, Op, Platypus, Prim, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.
+1 additional image

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Histamine H4 receptor antibody
  Rabbit polyclonal antibody to Histamine H4 Receptor (histamine receptor H4)  
Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis. A. 30 ug Jurkat whole cell lysate/extract. B. 30 ug Raji whole cell lysate/extract. C. 30 ug NCI-H929 whole cell lysate/extract. 10 % SDS-PAGE. Histamine H4 Rec Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.
+1 additional image

Histamine H4 receptor antibody
  Rabbit polyclonal anti-HRH4 antibody  
Immunofluorescence analysis of LOVO cells, using HRH4 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H4 receptor antibody
  Rabbit polyclonal anti-KR2_VZVD antibody  
Western blot analysis of extracts from K562 cells, using KR2_VZVD Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H4 receptor antibody
  Rabbit Polyclonal Anti-Human H4 Histamine Receptor (extracellular)  
Western blot analysis of human chronic myelogenous leukemia (K562) (lanes 1 and 3) and human promyelocytic leukemia (HL-60) (lanes 2 and 4) cell lysates: 1, 2. Anti-Human H4 Histamine Receptor (extracellular) antibody, (1:400). 3, 4. Anti-Human H4 Histamine Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.
+1 additional image

Histamine H4 receptor antibody
  Rabbit Polyclonal Anti-HRH4 Antibody (Extracellular Domain)  
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

Histamine H4 receptor antibody
  Rabbit Polyclonal Anti-HRH4 Antibody (Cytoplasmic Domain)  
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.
+1 additional image

Histamine H4 receptor (C-term) antibody
Immunohistochemical staining of Formalin-fixed, Paraffin-embedded human liver tissue using anti-HRH4 antibody cat. no. SP4670P Rabbit Aff - Purified Hu, Mky, Prim E, ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH
+2 additional images

Histamine H4 receptor antibody
Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €230.00
  Assay Biotech

Histamine H4 receptor antibody
Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

HRH4 - human gene knockout kit via CRISPR
HRH4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HRH4 - human gene knockout kit via CRISPR
HRH4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HRH4 - human gene knockout kit via CRISPR
HRH4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HRH4 - human gene knockout kit via CRISPR
HRH4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hrh4 - mouse gene knockout kit via CRISPR
Hrh4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hrh4 - mouse gene knockout kit via CRISPR
Hrh4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hrh4 - mouse gene knockout kit via CRISPR
Hrh4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hrh4 - mouse gene knockout kit via CRISPR
Hrh4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

HRH4 overexpression lysate
HRH4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HRH4 (mGFP-tagged) - Human histamine receptor H4 (HRH4), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, HRH4 (mGFP-tagged) - Human histamine receptor H4 (HRH4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.
 

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  1. CRISPR (8)
  2. Human Lenti ORF Particle (4)
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Clonality
  1. Polyclonal (10)
Target
  1. Histamine H4 receptor (10)
Property
  1. 1st Cytopl. Dom. (1)
  2. C-term (1)
Reactivity
  1. Human (Hu) (10)
  2. Monkey (Mky) (4)
  3. Primate (Prim) (2)
  4. Bear (1)
  5. Bovine (Bov) (1)
  6. Canine (Can) (1)
  7. Equine (Eq) (1)
  8. Mouse (Ms) (1)
  9. Opossum (Op) (1)
  10. Platypus (1)
  11. Rabbit (Rb) (1)
  12. Rat (Rt) (1)
Applications
  1. Enzyme Immunoassay (E) (5)
  2. Immunocytochemistry/​Immunofluorescence (ICC/IF) (4)
  3. Western blot / Immunoblot (WB) (3)
  4. Paraffin Sections (P) (2)
Presentation
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  2. Purified (5)
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Images
  1. 1 image (10)
  2. 3+ images (1)
Images: Applications
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  2. IHC (3)
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Donor Vector
  1. GFP-Puro (2)
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  4. mBFP-Neo (2)
Manufacturer
  1. Acris - OriGene (25)
  2. Assay Biotech (2)
Service
  • OriGene EU
  • Acris Antibodies GmbH
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  • D-32052 Herford
  • Germany
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  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info@acris-online.de
  • orders: ordering@acris-online.de
 
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