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Histamine H4 receptor antibody

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Principal name

Histamine H4 receptor antibody

Alternative names for Histamine H4 receptor antibody

HH4R, GPCR105, HRH4, G-protein coupled receptor 105, GPRv53, SP9144, AXOR35, Pfi-013

SwissProt ID

Q91ZY1 (Rat), Q91ZY2 (Mouse), Q9H3N8 (Human)

Gene ID

59340 (HRH4)

Ncbi ID

NP_001137300.1, 9606, NP_001137300, NM_021624

Available reactivities

Hu (Human), Ms (Mouse), Eq (Equine), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB)

Background of Histamine H4 receptor antibody

Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion. The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. H4 Histamine Receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kise (MAPK) cascade. H4 Histamine Receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 Histamine Receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 Histamine Receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production. These studies indicate that H4 Histamine Receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.

SP4356P - Histamine H4 receptor
Figure 1. Immunohistochemical staining of Lymph node using anti- HRH4 antibody SP4356P.
SP4670P - Histamine H4 receptor
Immunohistochemical staining of Formalin-fixed, Paraffin-embedded human liver tissue using anti-HRH4 antibody cat. no. SP4670P
SP4670P - Histamine H4 receptor
Cells expressing vector only - immunostained with target antibody
SP4670P - Histamine H4 receptor
Cells expressing target protein - immunostained with target antibody
GTX71421 - Histamine H4 receptor
Lymph node
NLS3775 - Histamine H4 receptor
Lymph node
GTX100387 - Histamine H4 receptor
Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis.A. 30 μg HeLa whole cell lysate/extract B. 30 μg whole cell lysate/extract of HRH4 shRNA-transfected HeLa cells10 % SDS-PAGEHistamine H4 Receptor antibody (GTX100387) dilution: 1:500
GTX100387 - Histamine H4 receptor
Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis.A. 30 μg Jurkat whole cell lysate/extractB. 30 μg Raji whole cell lysate/extractC. 30 μg NCI-H929 whole cell lysate/extract10 % SDS-PAGEHistamine H4 Receptor antibody (GTX100387) dilution: 1:500
G372-1 - Histamine H4 receptor
Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide.
GTX31040 - Histamine H4 receptor
Immunohistochemistry: Histamine H4 Receptor antibody [GTX31040] - Staining of lymph node sections with anti-Histamine H4 Receptor antibody.
AP31136PU-N - Histamine H4 receptor
AP31136PU-N HRH4 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Lymph Node.
NBP1-90058 - Histamine H4 receptor
Immunohistochemistry-Paraffin: Histamine H4 Receptor Antibody [NBP1-90058] - Immunohistochemical staining of human corpus, uterine shows strong cytoplasmic positivity in glandular cells.
NBP1-90058 - Histamine H4 receptor
Western Blot: Histamine H4 Receptor Antibody [NBP1-90058] Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 | Lane 2: RT-4 | Lane 3: U-251 MG | Lane 4: Human Plasma | Lane 5: Liver | Lane 6: Tonsil
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Histamine H4 receptor (1st Cytopl. Dom.) antibody
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Ovary, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Eq, Hu, Mky, Ms, Op, Platypus, Prim, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.
+1 additional image

Published recently!

Histamine H4 receptor antibody
Histamine H4 Receptor antibody detects Histamine H4 Receptor protein by western blot analysis. A. 30 ug Jurkat whole cell lysate/extract. B. 30 ug Raji whole cell lysate/extract. C. 30 ug NCI-H929 whole cell lysate/extract. 10 % SDS-PAGE. Histamine H4 Rec Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.
+1 additional image

Histamine H4 receptor antibody
Immunofluorescence analysis of LOVO cells, using HRH4 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H4 receptor antibody
Western blot analysis of extracts from K562 cells, using KR2_VZVD Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Histamine H4 receptor antibody
Western blot analysis of human chronic myelogenous leukemia (K562) (lanes 1 and 3) and human promyelocytic leukemia (HL-60) (lanes 2 and 4) cell lysates: 1, 2. Anti-Human H4 Histamine Receptor (extracellular) antibody, (1:400). 3, 4. Anti-Human H4 Histamine Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.
+1 additional image

Histamine H4 receptor antibody
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

Histamine H4 receptor antibody
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.
+1 additional image

Histamine H4 receptor antibody
AP31136PU-N HRH4 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Lymph Node. Rabbit IgG Aff - Purified Hu P
50 µg / €460.00
  Acris Antibodies GmbH

Histamine H4 receptor (C-term) antibody
Immunohistochemical staining of Formalin-fixed, Paraffin-embedded human liver tissue using anti-HRH4 antibody cat. no. SP4670P Rabbit Aff - Purified Hu, Mky, Prim E, ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH
+2 additional images

Histamine H4 receptor antibody
Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €205.00
  Assay Biotech

Histamine H4 receptor antibody
Immunofluorescence analysis of LOVO cells, using HRH4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

Histamine H4 receptor antibody
Immunohistochemistry-Paraffin: Histamine H4 Receptor Antibody [NBP1-90058] - Immunohistochemical staining of human corpus, uterine shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.
+1 additional image

Histamine H4 receptor antibody
Lymph node Rabbit Aff - Purified Hu P
50 µl / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Histamine H4 receptor
Histamine H4 receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

HRH4 overexpression lysate
HRH4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

15 Item(s)

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  1. Lysate (1)
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Target
  1. Histamine H4 receptor (14)
Property
  1. 1st Cytopl. Dom. (1)
  2. C-term (1)
Reactivity
  1. Human (Hu) (13)
  2. Monkey (Mky) (4)
  3. Prim (2)
  4. Bear (1)
  5. Bovine (Bov) (1)
  6. Canine (Can) (1)
  7. Equine (Eq) (1)
  8. Mouse (Ms) (1)
  9. Opossum (Op) (1)
  10. Platypus (1)
  11. Rabbit (Rb) (1)
  12. Rat (Rt) (1)
Applications
  1. Enzyme Immunoassay (E) (5)
  2. Paraffin Sections (P) (5)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (4)
  4. Western blot / Immunoblot (WB) (4)
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Images
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  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Immunocytochemistry/​Immunofluorescence (ICC/IF) (3)
  3. IHC (3)
  4. Paraffin Sections (P) (3)
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Species (Protein)
  1. Human (1)
Source
  1. in vitro transl. (1)
Manufacturer
  1. Acris - OriGene (10)
  2. Assay Biotech (2)
  3. Novus Biologicals Inc. (2)
  4. Abnova Taiwan Corp. (1)
Service
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