Histone H1 antibody

Principal name

Histone H1 antibody

Alternative names for Histone H1 antibody

H1 Histone Family, H1F4, H1F5, Histone H1a, Histone H1b

Available reactivities

Hu (Human), Mam (Mammalia), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Sheep, Mouse, Chicken, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of Histone H1 antibody

Although histones are classified into a limited number of types of fractions with each particular fraction having a fundamentally distinct amino acid composition and sequence, numerous subfractions are observed due to the acetylation, methylation, and phosphorylation of various amino acid residues. Microheterogeneity or alteration of structure is dynamic such that the histones of a single cell type are found to vary during development. They are believed to play a role in gene activity and cellular metabolism. Histones are believed to be regularly arranged in the deep groove of the DNA helix. The recurring positive charges of the histones form electrostatic associations with the negatively charged phosphate groups of DNA making the DNA more stable and flexible. This allows for the supercoiling of the chromatin fibers. With the exception of H1, the primary structures of the calf thymus histones have been determined. Comparisons with the structures for histones from other sources indicate that the histones rank among the most highly conserved (low mutation rate) proteins in nature.

General readings

Neary BA et al. Serological homologies between H1 degrees and H5 include the carboxyl-terminal domain. J Biol Chem 260:15850-5 (1985). PubMed PMID: 2415523
Bustin M & Stollar BD Immunochemical specificity in lysine-rich histone subfractions. J Biol Chem 247:5716-21 (1972). PubMed PMID: 5066541
Stollar BD & Ward M Rabbit antibodies to histone fractions as specific reagents for preparative and comparative studies. J Biol Chem 245:1261-6 (1970). PubMed PMID: 5442820
4. Zhu, G., et al. Histone H1 proteins act as receptors for the 987P fimbriae of enterotoxigenic Escherichia coli. J. Biol. Chem. 280(24):23057-23065, 2005.
5. Wondrak, G.T., et al. HIstone carbonylation in vivo and in vitro. Biochem J. 351(3):769-777, 2000.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Histone H1 antibody

Histone H1 Mouse IgG2a AE-4 Purified Hu C, E, ICC/IF, IP, P, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

Histone H1 antibody

Histone H1 Mouse IgG1 AE-4 Purified Hu C, E, ICC/IF, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

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