HLA class I alpha E / HLA-E antibody

Principal name

HLA class I alpha E / HLA-E antibody

Alternative names for HLA class I alpha E / HLA-E antibody

HLA-6.2, HLAE, MHC class I antigen E, HLA class I histocompatibility antigen, alpha chain E

SwissProt ID

P13747 (Human)

Gene ID

3133 (HLA-E)

Available reactivities

Hu (Human), Prim (Primate)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of HLA class I alpha E / HLA-E antibody

HLA-E (human leukocyte antigen-E) is a conserved class I major histocompatibility molecule. It binds to the leader peptide derived from the polymorphic classical MHC molecules HLA-A, HLA-B and HLA-C. This peptide binding stabilizes the HLA-E protein and allows it to migrate to the cell surface. HLA-E then interacts with CD94/NKG2A receptors on natural killer cells. This interaction inhibits natural killer cell-mediated lysis of cells displaying HLA-E. In virally infected cells or tumor cells, down-regulation of HLA-A, HLA-B and HLA-C production prevents stabilization of HLA-E by the leader peptide. Under these circumstances, HLA-E is degraded before it reaches the cell surface and the cell is then vulnerable to lysis by natural killer cells.

General readings

1. Coupel, S., et al., Blood 109, 2806-2814 (2007)
2. Menier, C., et al., Hum. Immunol. 64, 315-26 (2003)
3. Marin, R., et al., Immunogenetics 54, 767-75 (2003)
Clone MEM-E/02 is used in references 1 and 2.

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class I alpha E / HLA-E antibody

  Mouse Anti-Human HLA-E Purified (25 ug)  
Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human HLA-E Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Cells in the lymphocyte gate were used for analysis. Mouse 3D12HLA-E Purified Hu F, IP, WB
25 µg / €120.00
  OriGene Technologies, Inc.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/08 Aff - Purified Hu F, IP
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/07). Mouse IgG1 MEM-E/07 Biotin Hu F
0.1 mg / €330.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/07). Mouse IgG1 MEM-E/07 Aff - Purified Hu F, IP, P
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Flow cytometric analysis of HLA-E expression on LCL721 cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26570AF-N to the cells Mouse IgG1 4D12 Azide Free Hu F
0.1 mg / €360.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Western blot anaylsis: SM3053A HLA-E antibody staining of Human Placenta extracts Mouse IgG1 MEM-E/02 Azide Free Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry: SM3053P HLA-E antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen at 10 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 MEM-E/02 Purified Hu, Prim P, WB
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/02 Purified Hu WB
0.2 mg / €580.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/06). Mouse IgG1 MEM-E/06 Purified Hu, Prim F, IP, P
0.1 mg / €250.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HLA class I alpha E / HLA-E

  Recombinant protein of human major histocompatibility complex, class I, E (HLA-E)  
HLA class I alpha E / HLA-E Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HLA (mGFP-tagged) - Human major histocompatibility complex, class I, E (HLA-E), 200 uL, >10^7 TU/mL

Lenti ORF particles, HLA (mGFP-tagged) - Human major histocompatibility complex, class I, E (HLA-E), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

11 Item(s)

per page
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