HLA class I alpha E / HLA-E antibody

Principal name

HLA class I alpha E / HLA-E antibody

Alternative names for HLA class I alpha E / HLA-E antibody

HLA-6.2, HLAE, MHC class I antigen E, HLA class I histocompatibility antigen, alpha chain E

SwissProt ID

P13747 (Human)

Gene ID

3133 (HLA-E)

Available reactivities

Hu (Human), Prim (Primate), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of HLA class I alpha E / HLA-E antibody

HLA-E (human leukocyte antigen-E) is a conserved class I major histocompatibility molecule. It binds to the leader peptide derived from the polymorphic classical MHC molecules HLA-A, HLA-B and HLA-C. This peptide binding stabilizes the HLA-E protein and allows it to migrate to the cell surface. HLA-E then interacts with CD94/NKG2A receptors on natural killer cells. This interaction inhibits natural killer cell-mediated lysis of cells displaying HLA-E. In virally infected cells or tumor cells, down-regulation of HLA-A, HLA-B and HLA-C production prevents stabilization of HLA-E by the leader peptide. Under these circumstances, HLA-E is degraded before it reaches the cell surface and the cell is then vulnerable to lysis by natural killer cells.

General readings

Menier C et al. Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules. Hum Immunol 64:315-26 (2003). 1. Mavilio, D., Lombardo, G., Kinter, A., Fogli, M., La Sala, A., Ortolano, S., Farschi, A., Follmann, D., Gregg, R., Kovacs, C., Marcenaro, E., Pende, D., Moretta, A., and Fauci, A. S. (2006) Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection, 203, 2339-2350.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class I alpha E / HLA-E antibody

Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human HLA-E Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Cells in the lymphocyte gate were used for analysis. Mouse 3D12HLA-E Purified Hu F, IP, WB
25 µg / €120.00
  OriGene Technologies, Inc.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/08 Aff - Purified Hu F, IP
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/07). Mouse IgG1 MEM-E/07 Biotin Hu F
0.1 mg / €330.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/07). Mouse IgG1 MEM-E/07 Aff - Purified Hu F, IP, P
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Flow cytometric analysis of HLA-E expression on LCL721 cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26570AF-N to the cells Mouse IgG1 4D12 Azide Free Hu F
0.1 mg / €350.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Western blot anaylsis: SM3053A HLA-E antibody staining of Human Placenta extracts Mouse IgG1 MEM-E/02 Azide Free Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry: SM3053P HLA-E antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen at 10 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 MEM-E/02 Purified Hu, Prim P, WB
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/02 Purified Hu WB
0.2 mg / €580.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/06). Mouse IgG1 MEM-E/06 Purified Hu, Prim F, IP, P
0.1 mg / €250.00
  Acris Antibodies GmbH

HLA class I alpha E / HLA-E antibody

Western Blot analysis of HLA-E expression in transfected 293T cell line (H00003133-T01) by HLA-E MaxPab polyclonal antibody.

Lane 1: HLA-E transfected lysate(39.38 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

Immunoprecipitation of HLA-E transfected lysate using anti-HLA-E MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with HLA-E MaxPab mouse polyclonal antibody (B01) (H00003133-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

Western Blot analysis of HLA-E expression in transfected 293T cell line (H00003133-T02) by HLA-E MaxPab polyclonal antibody.

Lane 1: HLA-E transfected lysate(40.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/02 Hu P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/06 Hu F, IP
0.1 mg / €390.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/07 Hu F, IP
0.1 mg / €390.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/08 Hu F, IP
0.1 mg / €390.00
  Abnova Taiwan Corp.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/02 Aff - Purified Hu, Mky P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/08 Aff - Purified Hu F, IP
0.1 mg / €360.00
  Novus Biologicals Inc.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/06 Aff - Purified Hu, Mky F, IP, P
0.1 mg / €360.00
  Novus Biologicals Inc.

HLA class I alpha E / HLA-E antibody

HLA class I alpha E / HLA-E Mouse IgG1 MEM-E/07 Purified Hu F, IP, P
0.1 mg / €360.00
  Novus Biologicals Inc.

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