HLA class II DM beta / HLA-DMB antibody

Principal name

HLA class II DM beta / HLA-DMB antibody

Alternative names for HLA class II DM beta / HLA-DMB antibody

DMB, RING7, MHC class II antigen DMB, HLA class II histocompatibility antigen DM beta chain, Really interesting new gene 7 protein

SwissProt ID

P28068 (Human), P35737 (Mouse)

Gene ID

3109 (HLA-DMB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Dot blot (Dot)

Background of HLA class II DM beta / HLA-DMB antibody

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Fling, S. P., Arp, B., Pious, D. HLA-DMA and -DMB genes are both required for MHC class
II/peptide complex formation in antigen-presenting cells. Nature 368: 554-558, 1994.
2. Vogt AB, Kropshofer H (1999). "HLA-DM - an endosomal and lysosomal chaperone for the immune
system.". Trends Biochem. Sci.24 (4): 150–4.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DM beta / HLA-DMB antibody

  Rabbit polyclonal antibody to HLA-DMB (major histocompatibility complex, class II, DM beta)  
Western Blot analysis of HLA-DMB expression in transfected 293T cell line by HLA-DMB polyclonal antibody. A:Non-transfected lysate. B:HLA-DMB transfected lysate. 12% SDS PAGE. TA308239 diluted at 1:500 Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €415.00
  OriGene Technologies, Inc.

HLA class II DM beta / HLA-DMB (Center) antibody

Western blot analysis of HLA-DMB Antibody (Center) Cat.-No AP52052PU-N in Ramos cell line lysates (35ug/lane). This demonstrates the HLA-DMB antibody detected the HLA-DMB protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HLA class II DM beta / HLA-DMB

  Recombinant protein of human major histocompatibility complex, class II, DM beta (HLA-DMB)  
HLA class II DM beta / HLA-DMB Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.


Catalog No.    

HLA overexpression lysate

HLA overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

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