HLA class II DO alpha / HLA-DOA antibody

Principal name

HLA class II DO alpha / HLA-DOA antibody

Alternative names for HLA class II DO alpha / HLA-DOA antibody

MHC class II antigen DOA, MHC DZ alpha, MHC DN-alpha, HLA-DNA, HLA-DZA, HLA class II histocompatibility antigen DO alpha chain

SwissProt ID

P06340 (Human)

Gene ID

3111 (HLA-DOA)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of HLA class II DO alpha / HLA-DOA antibody

Reacts with HLA-DO, a heterodimer formed by DNalpha and DObeta subunits in B cells. DNalpha and DObeta are the products of the non-classical class II genes, HLA-DNA and HLA-DOB, respectively. DO forms tight complexes with DM in the endoplasmic reticulum and is thereby sorted to lysosomal vesicles during antigen processing and presentation. It is tightly associated with DM and it is selectively expressed on antigen-presenting cells, such as B cells, dendritic cells and thymic epithelial cells. DO can enhance the efficiency of peptide loading and has been found to stabilize DM at low pH, preserving its chaperon activity. DO-DM complexes are more efficient than DM in protecting empty DR molecules. Reports describe DO as a co-chaperone of DM. This antibody has also been reported to be suitable for western blot and immunoprecipitation.

General readings

Yoon,T., et al. (2012) Proc. Natl. Acad. Sci. U.S.A. 109 (28), 11276-11281Gieger,C., et al. (2012) Nature 480 (7376), 201-208

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DO alpha / HLA-DOA antibody

Western blot analysis of extracts from COLO cells, using HLA-DOA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HLA class II DO alpha / HLA-DOA antibody

Immunohistochemistry (IHC) analyzes of HLA-DOalpha antibody (Cat.-No.: AP21064PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

HLA class II DO alpha / HLA-DOA antibody

Western Blot analysis of HLA-DOA expression in transfected 293T cell line (H00003111-T01) by HLA-DOA MaxPab polyclonal antibody.

Lane 1: HLA-DOA transfected lysate(27.61 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA antibody

Western Blot analysis of HLA-DOA expression in transfected 293T cell line (H00003111-T01) by HLA-DOA MaxPab polyclonal antibody.

Lane 1: HLA-DOA transfected lysate(27.61 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA antibody

Western Blot analysis of HLA-DOA expression in transfected 293T cell line (H00003111-T02) by HLA-DOA MaxPab polyclonal antibody.

Lane 1: HLA-DOA transfected lysate(27.5 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA antibody

Western Blot analysis of HLA-DOA expression in transfected 293T cell line (H00003111-T02) by HLA-DOA MaxPab polyclonal antibody.

Lane 1: HLA-DOA transfected lysate(27.5 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA antibody

Western Blot analysis of HLA-DOA expression in transfected 293T cell line (H00003111-T02) by HLA-DOA MaxPab polyclonal antibody.

Lane 1: HLA-DOA transfected lysate(27.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA antibody

Western Blot analysis of HLA-DOA expression in transfected 293T cell line (H00003111-T02) by HLA-DOA MaxPab polyclonal antibody.

Lane 1: HLA-DOA transfected lysate(27.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA antibody

Western blot analysis of extracts from COLO cells, using HLA-DOA Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

HLA class II DO alpha / HLA-DOA antibody

Western blot analysis of extracts from COLO cells, using HLA-DOA Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

HLA class II DO alpha / HLA-DOA antibody

HLA class II DO alpha / HLA-DOA Rabbit Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

HLA class II DO alpha / HLA-DOA antibody

HLA class II DO alpha / HLA-DOA Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

HLA class II DO alpha / HLA-DOA antibody

HLA class II DO alpha / HLA-DOA Rabbit IgG Aff - Purified Hu E, WB
50 µg / €290.00
  Novus Biologicals Inc.

HLA class II DO alpha / HLA-DOA antibody

Immunohistochemistry-Paraffin: HLA DOA Antibody [NBP1-91993] Immunohistochemical staining of human tonsil shows strong granular cytoplasmic positivity in non-germinal center cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HLA class II DO alpha / HLA-DOA (26-217, His-tag)

HLA class II DO alpha / HLA-DOA Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

HLA class II DO alpha / HLA-DOA (26-217, His-tag)

HLA class II DO alpha / HLA-DOA Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

HLA class II DO alpha / HLA-DOA

HLA class II DO alpha / HLA-DOA Human
2 µg / €300.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA

HLA class II DO alpha / HLA-DOA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

HLA class II DO alpha / HLA-DOA

HLA class II DO alpha / HLA-DOA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HLA-DOA 293T Cell Transient Overexpression Lysate(Denatured)

HLA-DOA 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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