HLA class II DQ alpha 1 / HLA-DQA1 antibody

Principal name

HLA class II DQ alpha 1 / HLA-DQA1 antibody

Alternative names for HLA class II DQ alpha 1 / HLA-DQA1 antibody

DC-1 alpha chain, DC-alpha, HLA-DCA, MHC class II DQA1, HLA class II histocompatibility antigen DQ(3) alpha chain

SwissProt ID

P01909 (Human), P14439 (Mouse)

Gene ID

3117 (HLA-DQA1)

Available reactivities

Bov (Bovine), Sh (Sheep), Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of HLA class II DQ alpha 1 / HLA-DQA1 antibody

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

General readings

Donaldson, P.T., et al. J. Hepatol. 53(6):1049-1053(2010)
Noble, J.A., et al. Diabetes 59(11):2972-2979(2010)
Ferreira, R.C., et al. Nat. Genet. 42(9):777-780(2010)
Ovsyannikova, I.G., et al. PLoS ONE 5 (7), E11806 (2010)
Xun, Y.H., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23(6):430-433(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DQ alpha 1 / HLA-DQA1 (Center) antibody

Western blot analysis of HLA-DQA1 Antibody (Center) Cat.-No AP52053PU-N in K562 cell line lysates (35ug/lane). This demonstrates the HLA-DQA1 antibody detected the HLA-DQA1 protein (arrow). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HLA class II DQ alpha 1 / HLA-DQA1 antibody

HLA class II  DQ alpha 1 / HLA-DQA1 Mouse IgG1 VPM36 Supernatant Bov, Sh C, E, F, IP, P
2 ml / €450.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HLA class II DQ alpha 1 / HLA-DQA1

  Recombinant protein of human major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1)  
HLA class II  DQ alpha 1 / HLA-DQA1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HLA (mGFP-tagged) - Human major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), 200 uL, >10^7 TU/mL

Lenti ORF particles, HLA (mGFP-tagged) - Human major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, HLA (Myc-DDK tagged) - Human major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, HLA (Myc-DDK tagged) - Human major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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