HLA class II DQ alpha 1 / HLA-DQA1 antibody

Principal name

HLA class II DQ alpha 1 / HLA-DQA1 antibody

Alternative names for HLA class II DQ alpha 1 / HLA-DQA1 antibody

DC-1 alpha chain, DC-alpha, HLA-DCA, MHC class II DQA1, HLA class II histocompatibility antigen DQ(3) alpha chain

SwissProt ID

P01909 (Human), P14439 (Mouse)

Gene ID

100133678 (LOC100133678), 3117 (HLA-DQA1)

Available reactivities

Bov (Bovine), Sh (Sheep), Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Cytotoxicity Assay (CT), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of HLA class II DQ alpha 1 / HLA-DQA1 antibody

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Donaldson, P.T., et al. J. Hepatol. 53(6):1049-1053(2010)
Noble, J.A., et al. Diabetes 59(11):2972-2979(2010)
Ferreira, R.C., et al. Nat. Genet. 42(9):777-780(2010)
Ovsyannikova, I.G., et al. PLoS ONE 5 (7), E11806 (2010)
Xun, Y.H., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23(6):430-433(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DQ alpha 1 / HLA-DQA1 (Center) antibody

Western blot analysis of HLA-DQA1 Antibody (Center) Cat.-No AP52053PU-N in K562 cell line lysates (35ug/lane). This demonstrates the HLA-DQA1 antibody detected the HLA-DQA1 protein (arrow). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HLA class II DQ alpha 1 / HLA-DQA1 antibody

HLA class II  DQ alpha 1 / HLA-DQA1 Mouse IgG1 VPM36 Supernatant Bov, Sh C, E, F, IP, P
2 ml / €450.00
  Acris Antibodies GmbH

HLA class II DQ alpha 1 / HLA-DQA1 antibody

Western Blot analysis of HLA-DQA1 expression in transfected 293T cell line (H00003117-T02) by HLA-DQA1 MaxPab polyclonal antibody.

Lane 1: HLA-DQA1 transfected lysate(28.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HLA class II DQ alpha 1 / HLA-DQA1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CD74 and HLA-DQA1. HeLa cells were stained with anti-CD74 rabbit purified polyclonal 1:1200 and anti-HLA-DQA1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 1A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HLA class II DQ alpha 1 / HLA-DQA1 antibody

HLA class II  DQ alpha 1 / HLA-DQA1 Mouse IgG2a 7.5.10.1 Purified Can C, CT, FN, ICC/IF
1 ml / €360.00
  Novus Biologicals Inc.

HLA class II DQ alpha 1 / HLA-DQA1 antibody

Immunohistochemistry-Paraffin: HLA DQA1 Antibody [NBP1-84550] - Immunohistochemistry-Paraffin: HLA DQA1 Antibody [NBP1-84550] Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HLA class II DQ alpha 1 / HLA-DQA1

HLA class II  DQ alpha 1 / HLA-DQA1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

HLA class II DQ alpha 1 / HLA-DQA1

HLA class II  DQ alpha 1 / HLA-DQA1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

HLA class II DQ alpha 1 / HLA-DQA1

HLA class II  DQ alpha 1 / HLA-DQA1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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