HLA Class II DR antibody

Principal name

HLA Class II DR antibody

Alternative names for HLA Class II DR antibody

HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Mky (Monkey), Bab (Baboon)

Available hosts

Mouse, Rat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Radioimmunoassay (R)

Background of HLA Class II DR antibody

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II alpha/beta dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.

General readings

1. IL-4 and granulocyte-macrophage colony-stimulating factor selectively increase HLA-DR and HLA-DP antigens but not HLA-DQ antigens on human monocytes. Gerrard T.L., Dyer D.R., Mostowski H.S., J. Immunol. 1990 June, 1;144(12): 4670-4.
2. Structural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules. Karp D.R., Teletski C.L., Jaraquemada D., Maloy W.L., Coligan J.E., Long E.O.,
J. Exp. Med. 1990 March ;171(3):615-28.
3. Trans-activation of HLA-DR gene by hepatitis B virus X gene product. Hu K.Q., Vierling J.M., Siddiqui A., Proc. Natl. Acad. Sci. USA 1990 SEPT.; 87(18):7140-4.
4. Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma. Verfaillie C., Blakolmer K., McGlave P., J. Exp. Med. 1990 Aug.: 172(2):509-2.
5. Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+ CD8+ DR+ CD25- T cell population. Pantaleo G., Keonig S., Baseler M., Lane H.C., Fauci A.S., J. Immunol. 1990 Mar ; 144(5):1696-704.
6. Increased circulating HLA-DR+ CD4+ T cells in systemic lupus erythematosus: alterations associated with prednisolone therapy. Raziuddin S., Nur M.A., al-Wabel A.A., Scand. J. Immunol. 1990 Feb.:31(2):139-45.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA Class II DR antibody

HLA Class II DR Mouse IgG2a 423L FITC Hu, Mky F
100 Tests / €270.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG1 HL-12 Purified Hu C, E, F, ICC/IF, IP, WB
0.2 mg / €530.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Surface staining of human peripheral blood cells with anti-human HLA-DR (MEM-12) FITC. Mouse IgG1 MEM-12 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Surface staining of human peripheral blood cells with anti-human HLA-DR (MEM-12) FITC. Mouse IgG1 MEM-12 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Surface staining of human peripheral blood cells with anti-human HLA-DR antibody (MEM-12) FITC. Mouse IgG1 MEM-12 Aff - Purified Hu F, IP, WB
0.1 mg / €220.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Surface staining of human peripheral blood cells with anti-human HLA-DR (MEM-12) FITC. Mouse IgG1 MEM-12 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG2a 423L Biotin Hu, Mky F
100 Tests / €270.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG2a 423L Purified Hu, Mky F
0.1 mg / €240.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Figure 1. Peripheral blood lymphocytes stained with PE labeled anti-HLA-DR (AM05204RP-N). Mouse IgG2a 423L PE Hu, Mky F
100 Tests / €300.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Immunohistochemistry on frozen sections: Staining with AM26129PU-N on human tonsil. Mouse IgG2b EDU-1 Aff - Purified Hu C, F
0.1 mg / €280.00
  Acris Antibodies GmbH

HLA Class II DR antibody

A typical staining pattern with the B-F1 monoclonal antibody of lymphocytes Mouse IgG1 B-F1 Azide Free Hu F, IP
0.2 mg / €270.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG1 B-F1 Biotin Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

HLA Class II DR antibody

A typical staining pattern with the B-F1 monoclonal antibody of lymphocytes Mouse IgG1 B-F1 FITC Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

HLA Class II DR antibody

A typical staining pattern with the B-F1 monoclonal antibody of lymphocytes Mouse IgG1 B-F1 Purified Hu F, IP
2ml (200 Tests) / €250.00
  Acris Antibodies GmbH

HLA Class II DR antibody

A typical staining pattern with the B-F1 monoclonal antibody of lymphocytes Mouse IgG1 B-F1 PE Hu F
1ml (100 Tests) / €290.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 TDR31.1 Purified Hu C, F, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG2b LN-3 Supernatant Hu P
1 ml / €420.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG2b B-C10 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

HLA Class II DR antibody

HLA Class II DR Mouse IgG2b B-C10 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

HLA Class II DR antibody

Representative Data
Staining with clone BRA30 (anti-HLA-DR) monoclonal antibody is illustrated by flow cytometry of normal blood cells. Direct staining was performed using 10 µl FITC-conjugated antibody with 100 µl blood sample. Mouse IgG2a BRA30 FITC Hu F, ICC/IF
100 Tests / €350.00
  Acris Antibodies GmbH

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