HLA class II DR beta 1 / HLA-DRB1 antibody

Principal name

HLA class II DR beta 1 / HLA-DRB1 antibody

Alternative names for HLA class II DR beta 1 / HLA-DRB1 antibody

MHC class II antigen DRB1, DR1, DR-1, HLA class II histocompatibility antigen, DRB1-1 beta chain

SwissProt ID

P04229 (Human), Q5Y7E9 (Human)

Ncbi ID

9606

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection))

Background of HLA class II DR beta 1 / HLA-DRB1 antibody

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

General readings

This product has been used in:Brodsky FM et al. Monoclonal antibodies to HLA--DRw determinants. Tissue Antigens 16:30-48 (1980). PubMed PMID: 6162228
Brodsky FM et al. Monoclonal antibodies for analysis of the HLA system. Immunol Rev 47:3-61 (1979). PubMed PMID: 95015

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DR beta 1 / HLA-DRB1 antibody

Western blotting analysis of HLA-DR1 in Raji (A) and Jurkat (B) cell lines using MEM-267 antibody. Mouse IgG2b MEM-267 Aff - Purified Hu E, F, WB
0.1 mg / €220.00
  Acris Antibodies GmbH

HLA class II DR beta 1 / HLA-DRB1 antibody

HLA class II DR beta 1 / HLA-DRB1 Mouse IgG2b MEM-267 PE Hu F
0.1 mg / €330.00
  Acris Antibodies GmbH

HLA class II DR beta 1 / HLA-DRB1 (N-term) antibody

Western blot analysis of HLA-DRB1 Antibody (N-term) (AP17469PU-N) in WiDr cell line lysates (35 µg/lane). HLA-DRB1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HLA class II DR beta 1 / HLA-DRB1 antibody

HLA-DRB1 MaxPab polyclonal antibody. Western Blot analysis of HLA-DRB1 expression in human spleen. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

HLA class II DR beta 1 / HLA-DRB1 antibody

Western Blot analysis of HLA-DRB1 expression in transfected 293T cell line (H00003123-T04) by HLA-DRB1 MaxPab polyclonal antibody.

Lane 1: HLA-DRB1 transfected lysate(30.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HLA class II DR beta 1 / HLA-DRB1 antibody

HLA class II DR beta 1 / HLA-DRB1 Mouse IgG2b MEM-267 Hu
0.1 mg / €470.00
  Abnova Taiwan Corp.

HLA class II DR beta 1 / HLA-DRB1 antibody

HLA class II DR beta 1 / HLA-DRB1 Mouse IgG2b MEM-267 PE Hu F
0.1 mg / €400.00
  Abnova Taiwan Corp.

HLA class II DR beta 1 / HLA-DRB1 antibody

HLA class II DR beta 1 / HLA-DRB1 Mouse IgG1 DA2 Purified Hu C, E, F, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

HLA class II DR beta 1 / HLA-DRB1 antibody

HLA DR Antibody (MEM-267) [NB500-579]-Western blotting analysis of HLA-DR1 in Raji (A) and Jurkat (B) cell lines using MEM-267 antibody Mouse IgG2b MEM-267 Purified Hu E, F, WB
0.1 mg / €340.00
  Novus Biologicals Inc.

HLA class II DR beta 1 / HLA-DRB1 antibody

Western  Blot:  HLA DRB1 Antibody [NBP1-33525] – Western blot analysis of HLA DRB1 on H1299 lysates using NBP1-33525 at a dilution of 1:1000. 30ug whole cell lysate loaded on 12% SDS PAGE gel. Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HLA class II DR beta 1 / HLA-DRB1 (30-227, His-tag)

HLA class II DR beta 1 / HLA-DRB1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

HLA class II DR beta 1 / HLA-DRB1 (30-227, His-tag)

HLA class II DR beta 1 / HLA-DRB1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

12 Item(s)

per page
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