HLA class II DR beta 1 / HLA-DRB1 antibody

Principal name

HLA class II DR beta 1 / HLA-DRB1 antibody

Alternative names for HLA class II DR beta 1 / HLA-DRB1 antibody

MHC class II antigen DRB1, DR1, DR-1, HLA class II histocompatibility antigen, DRB1-1 beta chain

SwissProt ID

P04229 (Human), Q5Y7E9 (Human)

Ncbi ID

9606

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection))

Background of HLA class II DR beta 1 / HLA-DRB1 antibody

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

General readings

This product has been used in:Brodsky FM et al. Monoclonal antibodies to HLA--DRw determinants. Tissue Antigens 16:30-48 (1980). PubMed PMID: 6162228
Brodsky FM et al. Monoclonal antibodies for analysis of the HLA system. Immunol Rev 47:3-61 (1979). PubMed PMID: 95015

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DR beta 1 / HLA-DRB1 (N-term) antibody

Western blot analysis of HLA-DRB1 Antibody (N-term) (AP17469PU-N) in WiDr cell line lysates (35 µg/lane). HLA-DRB1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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