HLA class II DR beta 3 / HLA-DRB3 antibody
Principal name
HLA class II DR beta 3 / HLA-DRB3 antibody
Alternative names for HLA class II DR beta 3 / HLA-DRB3 antibody
MHC class II antigen DRB3, HLA class II histocompatibility antigen DRB3-1 beta chain
SwissProt ID
P79483 (Human)
Gene ID
3125 (HLA-DRB3)
Ncbi ID
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)
Background of HLA class II DR beta 3 / HLA-DRB3 antibody
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA308897 | HLA class II DR beta 3 / HLA-DRB3 antibody |
||||||
| Rabbit polyclonal antibody to HLA-DRB3 (major histocompatibility complex, class II, DR beta 3) | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu | ICC/IF |
0.1 ml /
€325.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA327100 | HLA class II DR beta 3 / HLA-DRB3 antibody |
||||||
| HLA-DRB3 Rabbit Polyclonal Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€325.00
|
|
| OriGene Technologies, Inc. | |||||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY411623 | HLA overexpression lysate |
|
 |
0.1 mg /
€280.00
|
|
| OriGene Technologies, Inc. |
