HLA class II DRB5 beta / HLA-DRB5 antibody

Principal name

HLA class II DRB5 beta / HLA-DRB5 antibody

Alternative names for HLA class II DRB5 beta / HLA-DRB5 antibody

DR beta-5, DR2-beta-2, Dw2, MHC class II antigen DRB5, HLA class II histocompatibility antigen, DRB5 beta chain

SwissProt ID

Q30154 (Human)

Gene ID

3127 (HLA-DRB5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P)

Background of HLA class II DRB5 beta / HLA-DRB5 antibody

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

General readings

Asano, K., et al. Nat. Genet. 41(12):1325-1329(2009)
Barrett, J.C., et al. Nat. Genet. 41(12):1330-1334(2009)
Montano-Loza, A.J., et al. Liver Int. 29(10):1543-1551(2009)
Lincoln, M.R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(18):7542-7547(2009)
Zepeda-Gomez, S., et al. Immunol. Invest. 38 (3-4), 276-283 (2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DRB5 beta / HLA-DRB5 antibody

HLA-DRB5 MaxPab rabbit polyclonal antibody. Western Blot analysis of HLA-DRB5 expression in human kidney. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

HLA class II DRB5 beta / HLA-DRB5 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma reacted with HLA-DRB5 Antibody (Center) Cat.-No AP52055PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HLA class II DRB5 beta / HLA-DRB5 antibody

Western Blot analysis of HLA-DRB5 expression in transfected 293T cell line (H00003127-T01) by HLA-DRB5 MaxPab polyclonal antibody.

Lane 1: HLA-DRB5 transfected lysate(29.37 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

HLA class II DRB5 beta / HLA-DRB5 antibody

HLA class II DRB5 beta / HLA-DRB5 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

HLA class II DRB5 beta / HLA-DRB5 antibody

Western Blot analysis of HLA-DRB5 expression in transfected 293T cell line (H00003127-T02) by HLA-DRB5 MaxPab polyclonal antibody.

Lane 1: HLA-DRB5 transfected lysate(29.26 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

HLA class II DRB5 beta / HLA-DRB5 antibody

HLA-DRB5 MaxPab rabbit polyclonal antibody. Western Blot analysis of HLA-DRB5 expression in human kidney. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HLA class II DRB5 beta / HLA-DRB5 antibody

HLA class II DRB5 beta / HLA-DRB5 Mouse IgG2b 7.3.19.1 Aff - Purified Hu ICC/IF
0.5 ml / €400.00
  Novus Biologicals Inc.

Antibody Pairs

Catalog No.    

HLA-DRB5 (Human) IP-WB Antibody Pair

HLA-DRB5 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HLA-DRB5 293T Cell Transient Overexpression Lysate(Denatured)

HLA-DRB5 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HLA-DRB5 293T Cell Transient Overexpression Lysate(Denatured)

HLA-DRB5 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HLA overexpression lysate

HLA overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

11 Item(s)

per page
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