HLA class II DRB5 beta / HLA-DRB5 antibody

Principal name

HLA class II DRB5 beta / HLA-DRB5 antibody

Alternative names for HLA class II DRB5 beta / HLA-DRB5 antibody

DR beta-5, DR2-beta-2, Dw2, MHC class II antigen DRB5, HLA class II histocompatibility antigen, DRB5 beta chain

SwissProt ID

Q30154 (Human)

Gene ID

3127 (HLA-DRB5)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of HLA class II DRB5 beta / HLA-DRB5 antibody

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

General readings

Asano, K., et al. Nat. Genet. 41(12):1325-1329(2009)
Barrett, J.C., et al. Nat. Genet. 41(12):1330-1334(2009)
Montano-Loza, A.J., et al. Liver Int. 29(10):1543-1551(2009)
Lincoln, M.R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(18):7542-7547(2009)
Zepeda-Gomez, S., et al. Immunol. Invest. 38 (3-4), 276-283 (2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HLA class II DRB5 beta / HLA-DRB5 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma reacted with HLA-DRB5 Antibody (Center) Cat.-No AP52055PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH

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