HMG-CoA lyase / HMGCL antibody

Principal name

HMG-CoA lyase / HMGCL antibody

Alternative names for HMG-CoA lyase / HMGCL antibody

mitochondrial Hydroxymethylglutaryl-CoA lyase

SwissProt ID

P35914 (Human), P35915 (Chick), P38060 (Mouse), P97519 (Rat), Q29448 (Bovin)

Gene ID

3155 (HMGCL), 79238 (Hmgcl)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Dros (Drosophila), Ze (Zebrafish), Chk (Chicken)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of HMG-CoA lyase / HMGCL antibody

HMGCL, also known as hydroxymethylglutaryl-CoA lyase, is a mitochondrial matrix protein that belongs to the HMG-CoA lyase family. It exists as a homodimer and participates in leucine catabolism and ketogenesis, the hepatic synthesis of ketone bodies that, during fasting, provide a major source of energy for heart, brain and kidney. More specifically, it catalyzes the final step of these processes, the cleavage of 3-hydroxy-3-methylglutaryl-CoA to acetoacetic acid and acetyl-CoA.

General readings

Fu, Z., et al. J. Biol. Chem. 285(34):26341-26349(2010)
Pierron, S., et al. Arch Pediatr 17(1):10-13(2010)
Menao, S., et al. Hum. Mutat. 30 (3), E520-E529 (2009)
Lin, W.D., et al. Clin. Chim. Acta 401 (1-2), 33-36 (2009)
Carrasco, P., et al. Mol. Genet. Metab. 91(2):120-127(2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HMG-CoA lyase / HMGCL antibody

HMGCL antibody detects HMGCL protein by Western blot analysis. A. 50 ug mouse liver lysate/extract. 10 % SDS-PAGE. HMGCL antibody (TA308677) dilution: 1:10000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

HMG-CoA lyase / HMGCL antibody

Host: Rabbit; Target Name: Hmgcl; Sample Tissue: Rat Thymus lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

HMG-CoA lyase / HMGCL (Center) antibody

Western blot analysis of HMG-CoA lyase / HMGCL Antibody (Center) Cat.-No AP52061PU-N in WiDr cell line lysates (35ug/lane). This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

HMG-CoA lyase / HMGCL antibody

HMG-CoA lyase / HMGCL Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

HMG-CoA lyase / HMGCL antibody

HMG-CoA lyase / HMGCL Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

HMG-CoA lyase / HMGCL antibody

Western Blot analysis of HMGCL expression in transfected 293T cell line (H00003155-T01) by HMGCL MaxPab polyclonal antibody.

Lane 1: HMGCL transfected lysate(34.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

HMG-CoA lyase / HMGCL antibody

Western Blot analysis of HMGCL expression in transfected 293T cell line by HMGCL monoclonal antibody (M01), clone 4F4-D1.

Lane 1: HMGCL transfected lysate(34.4 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 4F4-D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

HMG-CoA lyase / HMGCL antibody

Human Liver; WB Suggested Anti-HMGCL Antibody Titration: 1.25ug/ml. Positive Control: Human Liver; HMGCL antibody - N-terminal region (ARP41686_T100) in Human Liver cells using Western Blot Rabbit Aff - Purified Bov, Can, Dros, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

HMG-CoA lyase / HMGCL antibody

Human HepG2; WB Suggested Anti-HMGCL Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; HMGCL antibody - C-terminal region (ARP41687_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

HMG-CoA lyase / HMGCL antibody

HMG-CoA lyase / HMGCL Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

HMG-CoA lyase / HMGCL antibody

Western Blot: HMGCL Antibody [NBP1-58026] - This Anti-HMGCL antibody was used in Western Blot of fetal liver tissue lysate at a concentration of 1.25ug/ml. Rabbit Purified Bov, Can, Dros, Hu, Ms, Rt, Ze WB
0.1 mg / €360.00
  Novus Biologicals Inc.

HMG-CoA lyase / HMGCL antibody

Immunohistochemistry-Paraffin: HMGCL Antibody [NBP1-83251] - Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

HMG-CoA lyase / HMGCL

HMG-CoA lyase / HMGCL Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

HMG-CoA lyase / HMGCL (28-325, His-tag)

HMG-CoA lyase / HMGCL Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

HMG-CoA lyase / HMGCL (28-325, His-tag)

HMG-CoA lyase / HMGCL Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

HMG-CoA lyase / HMGCL

HMG-CoA lyase / HMGCL Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

HMG-CoA lyase / HMGCL

HMG-CoA lyase / HMGCL Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

HMGCL (Human) IP-WB Antibody Pair

HMGCL (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

HMGCL (Human) Matched Antibody Pair

HMGCL (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HMGCL overexpression lysate

HMGCL overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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